Recent advances in the treatment of insulin resistance targeting molecular and metabolic pathways: fighting a losing battle?

M Wolosowicz, S Prokopiuk, TW Kaminski - Medicina, 2022 - mdpi.com
Diabetes Mellitus (DM) is amongst the most notable causes of years of life lost worldwide
and its prevalence increases perpetually. The disease is characterized as multisystemic …

The pharmacological efficacy of baicalin in inflammatory diseases

Y Wen, Y Wang, C Zhao, B Zhao, J Wang - International Journal of …, 2023 - mdpi.com
Baicalin is one of the most abundant flavonoids found in the dried roots of Scutellaria
baicalensis Georgi (SBG) belonging to the genus Scutellaria. While baicalin is demonstrated …

Flavonoids improve type 2 diabetes mellitus and its complications: A review

X Yi, M Dong, N Guo, J Tian, P Lei, S Wang… - Frontiers in …, 2023 - frontiersin.org
The prevalence of type 2 diabetes mellitus (T2DM) is increasing every year. Medications are
currently the most common therapy for T2DM. However, these medications have certain …

Evaluation of Carbonic Anhydrase, Acetylcholinesterase, Butyrylcholinesterase, and α-Glycosidase Inhibition Effects and Antioxidant Activity of Baicalin Hydrate

L Durmaz, H Karagecili, İ Gulcin - Life, 2023 - mdpi.com
Baicalin is the foremost prevalent flavonoid found in Scutellaria baicalensis. It also
frequently occurs in many multi-herbal preparations utilized in Eastern countries. The current …

Baicalin promotes the activation of brown and white adipose tissue through AMPK/PGC1α pathway

Y Zhang, Z Zhang, Y Zhang, L Wu, L Gao, R Yao… - European Journal of …, 2022 - Elsevier
Obesity occurs when energy intake overtops energy expenditure. Promoting activation of
brown adipose tissue (BAT) and white adipose tissue (WAT) has been proven a promising …

The Anti-Diabetic Potential of Baicalin: Evidence from Rodent Studies

T Szkudelski, K Szkudelska - International Journal of Molecular Sciences, 2023 - mdpi.com
Baicalin is a biologically active flavonoid compound that benefits the organism in various
pathological conditions. Rodent studies have shown that this compound effectively …

Protective and therapeutic effects of Scutellaria baicalensis and its main active ingredients baicalin and baicalein against natural toxicities and physical hazards: a …

A Ahmadi, Z Mortazavi, S Mehri… - DARU Journal of …, 2022 - Springer
Objectives Scutellaria baicalensis (SB) has been traditionally used to combat a variety of
conditions ranging from ischemic heart disease to cancer. The protective effects of SB are …

Hyperinsulinemia-induced microglial mitochondrial dynamic and metabolic alterations lead to neuroinflammation in vivo and in vitro

X Yang, Y Xu, W Gao, L Wang, X Zhao, G Liu… - Frontiers in …, 2022 - frontiersin.org
Numerous studies have demonstrated that type 2 diabetes (T2D) is closely linked to the
occurrence of Alzheimer's disease (AD). Nevertheless, the underlying mechanisms for this …

Exploring the mechanism of diabetic cardiomyopathy treated with Qigui Qiangxin mixture based on UPLC-Q/TOF-MS, network pharmacology and experimental …

Q Han, Y Li, Y Yu, H Yuan, Z Wang, Y Guo, J Shi… - Scientific Reports, 2024 - nature.com
Despite its effectiveness in treating diabetic cardiomyopathy (DCM), Qigui Qiangxin Mixture
(QGQXM) remains unclear in terms of its active ingredients and specific mechanism of …

Baicalin suppresses macrophage JNK-mediated adipose tissue inflammation to mitigate insulin resistance in obesity

Z Zhu, M Yu, M Xu, X Ji, X Zong, Z Zhang… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Radix scutellariae (the root of Scutellaria baicalensis
Georgi) is a traditional Chinese medicine (TCM) used to treat a wide range of inflammation …