Spine dynamics in the brain, mental disorders and artificial neural networks
In the brain, most synapses are formed on minute protrusions known as dendritic spines.
Unlike their artificial intelligence counterparts, spines are not merely tuneable memory …
Unlike their artificial intelligence counterparts, spines are not merely tuneable memory …
Developmental mechanisms underlying the evolution of human cortical circuits
P Vanderhaeghen, F Polleux - Nature Reviews Neuroscience, 2023 - nature.com
The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …
higher cognitive functions. These capacities are tightly linked to an increase in the size and …
[HTML][HTML] Dendritic spine plasticity: function and mechanisms
K Runge, C Cardoso, A De Chevigny - Frontiers in synaptic …, 2020 - frontiersin.org
Dendritic spines are small protrusions studding neuronal dendrites, first described in 1888
by Ramón y Cajal using his famous Golgi stainings. Around 50 years later the advance of …
by Ramón y Cajal using his famous Golgi stainings. Around 50 years later the advance of …
A large-scale nanoscopy and biochemistry analysis of postsynaptic dendritic spines
MS Helm, TM Dankovich, S Mandad, B Rammner… - Nature …, 2021 - nature.com
Dendritic spines, the postsynaptic compartments of excitatory neurotransmission, have
different shapes classified from 'stubby'to 'mushroom-like'. Whereas mushroom spines are …
different shapes classified from 'stubby'to 'mushroom-like'. Whereas mushroom spines are …
Virtual histology of cortical thickness and shared neurobiology in 6 psychiatric disorders
Importance Large-scale neuroimaging studies have revealed group differences in cortical
thickness across many psychiatric disorders. The underlying neurobiology behind these …
thickness across many psychiatric disorders. The underlying neurobiology behind these …
Neuronal morphology and network properties modulate signal propagation in multi-layer feedforward network
The propagation and detection of weak signals play a vital role in the central nervous
system's information processing. In this paper, a biophysical two-compartment model is …
system's information processing. In this paper, a biophysical two-compartment model is …
Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases
LD Nguyen, BE Ehrlich - EMBO molecular medicine, 2020 - embopress.org
Chemotherapy is a life‐saving treatment for cancer patients, but also causes long‐term
cognitive impairment, or “chemobrain”, in survivors. However, several challenges, including …
cognitive impairment, or “chemobrain”, in survivors. However, several challenges, including …
Psychedelics and neural plasticity: therapeutic implications
Psychedelic drugs have reemerged as tools to treat several brain disorders. Cultural
attitudes toward them are changing, and scientists are once again investigating the neural …
attitudes toward them are changing, and scientists are once again investigating the neural …
[HTML][HTML] Regulation of actin dynamics during structural plasticity of dendritic spines: Signaling messengers and actin-binding proteins
Activity-dependent plasticity of synaptic structure and function plays an essential role in
neuronal development and in cognitive functions including learning and memory. The …
neuronal development and in cognitive functions including learning and memory. The …
Toward recovery in schizophrenia: Current concepts, findings, and future research directions
T Onitsuka, Y Hirano, T Nakazawa… - Psychiatry and …, 2022 - Wiley Online Library
Schizophrenia was initially defined as “dementia praecox” by E. Kraepelin, which implies
progressive deterioration. However, recent studies have revealed that early effective …
progressive deterioration. However, recent studies have revealed that early effective …