Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

More than 25 years after its discovery, the post-transcriptional gene regulation mechanism
termed RNAi is now transforming pharmaceutical development, proved by the recent FDA …

Inflammation‐associated diseases are very common clinically with a high incidence;
however, there is still a lack of effective treatments. Cell‐biomimetic nanoplatforms have led …

Although the prognosis of lupus nephritis (LN) has improved over the last few decades, 5–
20% of patients still progress to kidney failure. Hence, there is an unmet need to improve the …

The sensing of self RNA by the endosomal Toll-like receptors (TLRs) 7 and 8 initiates
pathogenic mechanisms underlying the autoimmune disease lupus. A blockade of the …

Defective α-galactosidase A (AGAL/GLA) due to missense or nonsense mutations in the
GLA gene results in accumulation of the glycosphingolipids globotriaosylceramide (Gb3) …

Calcineurin inhibitors (CNI) can suppress allo-and autoimmunity by suppressing T cell
function but also have anti-proteinuric effects by stabilizing the cellular components of the …

Laser capture microdissection and mass spectrometry (LCM/MS) is a technique that involves
dissection of glomeruli from paraffin-embedded biopsy tissue, followed by digestion of the …

The ongoing glomerular damage of infections is not limited to the most widely known form of
post-streptococcal glomerulonephritis, which is today less common in the Western world; …

Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE), a
polyclonal systemic autoimmunity directed against nuclear and other self-antigens. SLE/LN …