Key role of mesenchymal stromal cell interaction with macrophages in promoting repair of lung injury

M Jerkic, K Szaszi, JG Laffey, O Rotstein… - International Journal of …, 2023 - mdpi.com
Lung macrophages (Mφs) are essential for pulmonary innate immunity and host defense
due to their dynamic polarization and phenotype shifts. Mesenchymal stromal cells (MSCs) …

Quercetin alleviates lipopolysaccharide‑induced acute lung injury by inhibiting ferroptosis via the Sirt1/Nrf2/Gpx4 pathway

S Deng, J Li, L Li, S Lin, Y Yang… - International …, 2023 - spandidos-publications.com
Acute lung injury (ALI) causes high morbidity and mortality rates in critically ill patients, and
there are currently no effective therapeutic drugs. Ferroptosis is a newly discovered mode of …

Pathological role of inflammation in ocular disease progress and its targeting by mesenchymal stem cells (MSCs) and their exosome; current status and prospect

A Nouralishahi, N Fazlinejad, RDC Pecho… - … -Research and Practice, 2023 - Elsevier
Because of their unique capacity for differentiation to a diversity of cell lineages and
immunosuppressive properties, mesenchymal stem cells (MSC) are being looked at as a …

Chicoric acid presented NLRP3-mediated pyroptosis through mitochondrial damage by PDPK1 ubiquitination in an acute Lung injury model

W Zhang, M Zhao, Z Pu, Q Yin, Y Shui - The American Journal of …, 2023 - World Scientific
Chicoric acid (CA), a functional food ingredient, is a caffeic acid derivative that is mainly
found in lettuce, pulsatilla, and other natural plants. However, the anti-inflammatory effects of …

Bioengineered stem cell membrane functionalized nanoparticles combine anti-inflammatory and antimicrobial properties for sepsis treatment

L Lu, L Quan, J Li, J Yuan, X Nie, X Huang… - Journal of …, 2023 - Springer
Background Sepsis is a syndrome of physiological, pathological and biochemical
abnormalities caused by infection. Although the mortality rate is lower than before, many …

[HTML][HTML] Protective effect of soloxolone derivatives in carrageenan-and LPS-driven acute inflammation: Pharmacological profiling and their effects on key inflammation …

AV Sen'kova, IA Savin, KV Odarenko… - Biomedicine & …, 2023 - Elsevier
The anti-inflammatory potential of three cyanoenone-containing triterpenoids, including
soloxolone methyl (SM), soloxolone (S) and its novel derivative bearing at the C-30 …

Clinical Trials of Mesenchymal Stem Cells for the Treatment of COVID 19

E Zendedel, L Tayebi, M Nikbakht… - Current Stem Cell …, 2024 - ingentaconnect.com
Mesenchymal Stem Cells (MSCs) are being investigated as a treatment for a novel viral
disease owing to their immunomodulatory, anti-inflammatory, tissue repair and regeneration …

[HTML][HTML] Adipose tissue-derived mesenchymal stromal cells attenuate acute lung injury induced by trauma and haemorrhagic shock

Z Zhang, X Yang, Q Meng, Y Long, X Shi, Y Wang - Immunobiology, 2023 - Elsevier
Abstract Background Mesenchymal stromal cells (MSCs) have shown promising therapeutic
options for acute lung injury (ALI) caused by multiple factors. Here, we evaluated the …

Review of current and potential applications of mesenchymal stem cells in exotic animal species

VA Johnson - Journal of the American Veterinary Medical …, 2024 - Am Vet Med Assoc
The discovery that a population of cells derived from adult tissues had regenerative
properties and could be expanded and utilized therapeutically led to an abundance of …

Interplay between pulmonary epithelial stem cells and innate immune cells contribute to the repair and regeneration of ALI/ARDS

J Wang, X Peng, N Yuan, B Wang, S Chen… - Translational …, 2024 - Elsevier
Mammalian lung is the important organ for ventilation and exchange of air and blood. Fresh
air and venous blood are constantly delivered through the airway and vascular tree to the …