Glypicans are a family of heparan sulfate proteoglycans that are attached to the cell
membrane via a glycosylphosphatidylinositol anchor. Glypicans interact with multiple …

Results of immunotherapy in childhood solid cancer have been so far, with the exception of
neuroblastoma, quite disappointing. Lack of knowledge of the immune contexture of these …

Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related death
in the world, and curative systemic therapies are lacking. Chimeric antigen receptor (CAR) …

Glypican 3 (GPC3) is a heparan sulfate proteoglycan and cell surface oncofetal protein
which is highly expressed on a variety of pediatric solid embryonal tumors including the …

ABSTRACT A bispecific antibody (bsAb) can simultaneously bind two different epitopes or
antigens, allowing for multiple mechanistic functions with synergistic effects. BsAbs have …

The carcinoembryonic antigen glypican-3 (GPC3) is a good target of anticancer
immunotherapy against pediatric solid tumors expressing GPC3. In this non-randomized …

Though outcomes for pediatric cancer patients have significantly improved over the past
several decades, too many children still experience poor outcomes and survivors suffer …

Hepatocellular carcinoma is a substantial health concern. It is currently the third dominating
cause of mortality associated with cancer worldwide. The development of hepatocellular …

This review highlights the role of several immunomodulating elements contributing to the
tumor microenvironment of various pediatric renal tumors including Wilms tumor. The roles …

Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide with an overall
survival rate of less than 15% in developed countries. Despite attempts at new therapeutic …