Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Q Tuo, S Zhang, P Lei - Medicinal research reviews, 2022 - Wiley Online Library
Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

[PDF][PDF] VEGF in signaling and disease: beyond discovery and development

RS Apte, DS Chen, N Ferrara - Cell, 2019 - cell.com
The discovery of vascular endothelial-derived growth factor (VEGF) has revolutionized our
understanding of vasculogenesis and angiogenesis during development and physiological …

Uterine bleeding: how understanding endometrial physiology underpins menstrual health

V Jain, RR Chodankar, JA Maybin… - Nature reviews …, 2022 - nature.com
Menstruation is a physiological process that is typically uncomplicated. However, up to one
third of women globally will be affected by abnormal uterine bleeding (AUB) at some point in …

The treatment of impaired wound healing in diabetes: looking among old drugs

SF Spampinato, GI Caruso, R De Pasquale… - Pharmaceuticals, 2020 - mdpi.com
Chronic wounds often occur in patients with diabetes mellitus due to the impairment of
wound healing. This has negative consequences for both the patient and the medical …

[HTML][HTML] Physiology of the endometrium and regulation of menstruation

HOD Critchley, JA Maybin… - Physiological …, 2020 - journals.physiology.org
The physiological functions of the uterine endometrium (uterine lining) are preparation for
implantation, maintenance of pregnancy if implantation occurs, and menstruation in the …

Pathophysiological implications of hypoxia in human diseases

PS Chen, WT Chiu, PL Hsu, SC Lin, IC Peng… - Journal of biomedical …, 2020 - Springer
Oxygen is essentially required by most eukaryotic organisms as a scavenger to remove
harmful electron and hydrogen ions or as a critical substrate to ensure the proper execution …

Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment

W Li, F Li, X Zhang, HK Lin, C Xu - Signal transduction and targeted …, 2021 - nature.com
More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …

[HTML][HTML] Tumor hypoxia: impact on radiation therapy and molecular pathways

BS Sørensen, MR Horsman - Frontiers in oncology, 2020 - frontiersin.org
Tumor hypoxia is a common feature of the microenvironment in solid tumors, primarily due to
an inadequate, and heterogeneous vascular network. It is associated with resistance to …

Hypoxia and extracellular vesicles: A review on methods, vesicular cargo and functions

N Bister, C Pistono, B Huremagic… - Journal of …, 2020 - Wiley Online Library
Hypoxia is an essential hallmark of several serious diseases such as cardiovascular and
metabolic disorders and cancer. A decline in the tissue oxygen level induces hypoxic …

Endothelial–mesenchymal transition in atherosclerosis

C Souilhol, MC Harmsen, PC Evans… - Cardiovascular …, 2018 - academic.oup.com
Atherosclerosis is an inflammatory disease resulting in the hardening and thickening of the
wall of arteries and the formation of plaques, which comprise immune cells, mesenchymal …