Gut-liver axis: Pathophysiological concepts and clinical implications

H Tilg, TE Adolph, M Trauner - Cell metabolism, 2022 - cell.com
Bidirectional crosstalk along the gut-liver axis controls gastrointestinal health and disease
and exploits environmental and host mediators. Nutrients, microbial antigens, metabolites …

Advances in the diagnosis and treatment of non-alcoholic fatty liver disease

X Yin, X Guo, Z Liu, J Wang - International Journal of Molecular Sciences, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease that
affects approximately one-quarter of the global adult population, posing a significant threat …

Tumour extracellular vesicles and particles induce liver metabolic dysfunction

G Wang, J Li, L Bojmar, H Chen, Z Li, GC Tobias, M Hu… - Nature, 2023 - nature.com
Cancer alters the function of multiple organs beyond those targeted by metastasis,. Here we
show that inflammation, fatty liver and dysregulated metabolism are hallmarks of …

MASLD: a systemic metabolic disorder with cardiovascular and malignant complications

G Targher, CD Byrne, H Tilg - Gut, 2024 - gut.bmj.com
Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common chronic
liver disease globally and is currently estimated to affect up to 38% of the global adult …

Non-alcoholic fatty liver disease: pathophysiological concepts and treatment options

C Grander, F Grabherr, H Tilg - Cardiovascular Research, 2023 - academic.oup.com
The prevalence of non-alcoholic fatty liver disease (NAFLD) is continually increasing due to
the global obesity epidemic. NAFLD comprises a systemic metabolic disease accompanied …

Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis

B Zhou, Y Luo, N Ji, C Hu, Y Lu - Nature Metabolism, 2022 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is caused by imbalance in lipid metabolism. In this
study, we show that the hepatokine orosomucoid (ORM) 2 is a key regulator of de novo …

Association between non-alcoholic fatty liver disease and heavy metal exposure: a systematic review

P Sadighara, AH Abedini, N Irshad… - Biological trace element …, 2023 - Springer
Non-alcoholic fatty liver disease (NAFLD) is a debilitating disease with adverse effects
including cirrhosis and hepatocellular carcinoma. Heavy metals can cause severe …

NASH drug treatment development: challenges and lessons

H Tilg, CD Byrne, G Targher - The Lancet Gastroenterology & …, 2023 - thelancet.com
Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver
disease worldwide. Although NAFLD is tightly linked to obesity and type 2 diabetes, this liver …

Targeted modulation of gut microbiota by traditional Chinese medicine and natural products for liver disease therapy

LR Zhu, SS Li, WQ Zheng, WJ Ni, M Cai… - Frontiers in …, 2023 - frontiersin.org
The gut microbiota not only constitutes intestinal microenvironment homeostasis and human
health but also exerts indispensable roles in the occurrence and progression of multiple liver …

Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis

K Yang, J Chen, T Zhang, X Yuan, A Ge… - Frontiers in …, 2022 - frontiersin.org
Background Dietary polyphenol treatment of non-alcoholic fatty liver disease (NAFLD) is a
novel direction, and the existing clinical studies have little effective evidence for its …