Corticosteroids in ophthalmology: Drug delivery innovations, pharmacology, clinical applications, and future perspectives

SA Gaballa, UB Kompella, O Elgarhy… - Drug Delivery and …, 2021 - Springer
Corticosteroids remain the mainstay of the treatment for various ocular conditions affecting
the ocular surface, anterior and posterior segments of the eye due to their anti-inflammatory …

Rho kinase (ROCK) inhibitors and their therapeutic potential

Y Feng, PV LoGrasso, O Defert, R Li - Journal of medicinal …, 2016 - ACS Publications
Rho kinases (ROCKs) belong to the serine–threonine family, the inhibition of which affects
the function of many downstream substrates. As such, ROCK inhibitors have potential …

The many faces of the adamantyl group in drug design

J Liu, D Obando, V Liao, T Lifa, R Codd - European journal of medicinal …, 2011 - Elsevier
Adamantyl-based compounds are used clinically for the treatment of neurological
conditions, as anti-viral agents and as agents against type 2 diabetes. The value of the …

Recent advances in topical ocular drug delivery

VK Yellepeddi, S Palakurthi - Journal of Ocular Pharmacology and …, 2016 - liebertpub.com
Topical ocular drug delivery has been considered to be an ideal route of administration for
treatment of ocular diseases related to the anterior segment of the eye. However, topical …

[HTML][HTML] Treatment of non-infectious corneal injury: review of diagnostic agents, therapeutic medications, and future targets

DH Dang, KM Riaz, D Karamichos - Drugs, 2022 - Springer
Corneal injuries can occur secondary to traumatic, chemical, inflammatory, metabolic,
autoimmune, and iatrogenic causes. Ocular infection may frequently occur concurrent to …

[HTML][HTML] Intraocular pressure effects of common topical steroids for post-cataract inflammation: are they all the same?

U Pleyer, PG Ursell, P Rama - Ophthalmology and therapy, 2013 - Springer
The efficacy of topical corticosteroids as ocular anti-inflammatory agents following cataract
surgery is well-documented. They also help to prevent a number of complications …

[HTML][HTML] The therapeutic use of quercetin in ophthalmology: Recent applications

L Zhao, H Wang, X Du - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Quercetin is a natural flavonol antioxidant found in various plant sources and food samples.
It is well known for its notable curative effects on the treatment of ophthalmic diseases due to …

Management of seasonal allergic conjunctivitis: guide to therapy

BP Bielory, TP O'Brien, L Bielory - Acta ophthalmologica, 2012 - Wiley Online Library
Seasonal allergic conjunctivitis (SAC) is an inflammatory response of the conjunctiva
triggered by exposure to seasonal allergens. Treatment options for SAC include artificial …

[HTML][HTML] Impact of the topical ophthalmic corticosteroid loteprednol etabonate on intraocular pressure

JD Sheppard, TL Comstock, ME Cavet - Advances in therapy, 2016 - Springer
Corticosteroids are a mainstay therapeutic option for the treatment of ocular inflammation.
However, safety remains a concern for clinicians, particularly with long-term use. Though …

Cyclosporine A loaded SLNs: evaluation of cellular uptake and corneal cytotoxicity

EH Gokce, G Sandri, MC Bonferoni, S Rossi… - International journal of …, 2008 - Elsevier
Cyclosporine A (CsA) loaded solid lipid nanoparticles (SLNs) for topical ophthalmic
applications were prepared by high shear homogenization and ultrasound method using …