The antimicrobial peptide database is 20 years old: Recent developments and future directions

G Wang - Protein Science, 2023 - Wiley Online Library
Abstract In 2023, the Antimicrobial Peptide Database (currently available at https://aps.
unmc. edu) is 20‐years‐old. The timeline for the APD expansion in peptide entries …

Cross-talk and mutual shaping between the immune system and the microbiota during an oyster's life

D Destoumieux-Garzón… - … of the Royal …, 2024 - royalsocietypublishing.org
The Pacific oyster Crassostrea gigas lives in microbe-rich marine coastal systems subjected
to rapid environmental changes. It harbours a diversified and fluctuating microbiota that …

Novel technologies uncover novel 'anti'-microbial peptides in Hydra shaping the species-specific microbiome

A Klimovich, TCG Bosch - Philosophical Transactions of …, 2024 - royalsocietypublishing.org
The freshwater polyp Hydra uses an elaborate innate immune machinery to maintain its
specific microbiome. Major components of this toolkit are conserved Toll-like receptor (TLR) …

Hundreds of antimicrobial peptides create a selective barrier for insect gut symbionts

J Lachat, G Lextrait, R Jouan… - Proceedings of the …, 2024 - National Acad Sciences
The spatial organization of gut microbiota is crucial for the functioning of the gut ecosystem,
although the mechanisms that organize gut bacterial communities in microhabitats are only …

Cereal weevils' antimicrobial peptides: at the crosstalk between development, endosymbiosis and immune response

N Galambos, C Vincent-Monegat… - … of the Royal …, 2024 - royalsocietypublishing.org
Interactions between animals and microbes are ubiquitous in nature and strongly impact
animal physiology. These interactions are shaped by the host immune system, which …

The role of animal hosts in shaping gut microbiome variation

E Maritan, A Quagliariello, E Frago… - … of the Royal …, 2024 - royalsocietypublishing.org
Millions of years of co-evolution between animals and their associated microbial
communities have shaped and diversified the nature of their relationship. Studies continue …

Evolutionary immunology to explore original antiviral strategies

JL Imler, H Cai, C Meignin… - … Transactions of the …, 2024 - royalsocietypublishing.org
Over the past 25 years, the field of evolutionary developmental biology (evo–devo) has used
genomics and genetics to gain insight on the developmental mechanisms underlying the …

The conceptual foundations of innate immunity: Taking stock 30 years later

T Pradeu, BPHJ Thomma, SE Girardin, B Lemaitre - Immunity, 2024 - cell.com
While largely neglected over decades during which adaptive immunity captured most of the
attention, innate immune mechanisms have now become central to our understanding of …

How infection-triggered pathobionts influence virulence evolution

M Franz, RR Regoes, J Rolff - … Transactions of the …, 2024 - royalsocietypublishing.org
Host–pathogen interactions can be influenced by the host microbiota, as the microbiota can
facilitate or prevent pathogen infections. In addition, members of the microbiota can become …

[HTML][HTML] Suppression of Drosophila antifungal immunity by a parasite effector via blocking GNBP3 and GNBP-like 3, the dual receptors for β-glucans

M Lu, D Wei, J Shang, S Li, S Song, Y Luo, G Tang… - Cell Reports, 2024 - cell.com
The tactics used by animal pathogens to combat host immunity are largely unclear. Here, we
report the depiction of the virulence-required effector Tge1 deployed by the …