Immunotherapy, with an increasing number of therapeutic dimensions, is becoming an
important mode of treatment for cancer patients. The inhibition of immune checkpoints …

Immune checkpoint inhibitors (ICI) used for cancer immunotherapy were shown to boost the
existing anti-tumor immune response by preventing the inhibition of T cells by tumor cells …

The immune system is critical in modulating cancer progression, but knowledge of immune
composition, phenotype, and interactions with tumor is limited. We used multiplexed ion …

Recent years have seen significant efforts in understanding and modulating the immune
response in cancer. In this context, immunosuppressive cells, including regulatory T cells …

Purpose: Checkpoint molecules like programmed death-1 (PD-1) and T-cell immunoglobulin
mucin-3 (TIM-3) are negative immune regulators that may be upregulated in the setting of …

Adoptive immunotherapy using autologous T cells endowed with chimeric antigen receptors
(CAR) has emerged as a powerful means of treating cancer. However, a limitation of this …

Importance Immune checkpoint inhibitor therapy has shown benefit in various cancers, but
their potential in endometrial cancer (EC) is unknown. Observations Prediction of …

Purpose Blocking the interaction between the programmed cell death (PD)-1 protein and
one of its ligands, PD-L1, has been reported to have impressive antitumor responses …

The immune-modulating effects of radiotherapy (XRT) have gained considerable interest
recently, and there have been multiple reports of synergy between XRT and immunotherapy …

It is generally accepted that metabolism is able to shape the immune response. Only
recently we are gaining awareness that the metabolic crosstalk between different tumor …