When considering the control of gene expression, the focus has traditionally been on
transcriptional regulation. Recently, however, the large contribution made by mRNA decay …

The cytokine-encoding messenger RNA (mRNA) molecules transcribed in the nucleus
acquire a protein coat that facilitates nuclear export, influences cytoplasmic localization, and …

Messenger RNA decay is an essential step in gene expression to set mRNA abundance in
the cytoplasm. The binding of proteins and/or noncoding RNAs to specific recognition …

Dynamic changes of the lengths of mRNA poly (A) tails are catalysed by diverse
deadenylase enzymes. Modulating the length of the poly (A) tail of an mRNA is a …

mRNA decapping is a critical step in eukaryotic cytoplasmic mRNA turnover. Cytoplasmic
mRNA decapping is catalyzed by Dcp2 in conjunction with its coactivator Dcp1 and is …

RNA-binding proteins (RBPs) are key regulators of posttranscriptional gene expression and
control many important biological processes including cell proliferation, development, and …

In mammalian cells, mRNAs with AU-rich elements (AREs) are targeted for translational
silencing and rapid degradation. Here we present evidence that in human cells the proteins …

A considerable number of genes that code for AU-rich mRNAs including cytokines, growth
factors, transcriptional factors, and certain receptors are involved in both chronic …

Nuclear RNA-binding proteins can record pre-mRNA processing events in the structure of
messenger ribonucleoprotein particles (mRNPs). During initial rounds of translation, the …

Decapping is a critical step in the control of mRNA stability and the regulation of gene
expression. Two major decapping enzymes involved in mRNA turnover have been …