Comparative risk assessment of alcohol, tobacco, cannabis and other illicit drugs using the margin of exposure approach

DW Lachenmeier, J Rehm - Scientific reports, 2015 - nature.com
A comparative risk assessment of drugs including alcohol and tobacco using the margin of
exposure (MOE) approach was conducted. The MOE is defined as ratio between …

Laboratory testing in ethanol, methanol, ethylene glycol, and isopropanol toxicities

AS Church, MD Witting - The Journal of emergency medicine, 1997 - Elsevier
Toxicity from ethanol, methanol, ethylene glycol, and isopropyl alcohol varies widely, and
appropriate use of the available laboratory tests can aid in timely and specific treatment …

Alcohol intoxication in childhood and adolescence

A Lamminpää - Alcohol and alcoholism, 1995 - academic.oup.com
Coma and vomiting are the commonest symptoms in young teenagers intoxicated by
alcohol. Severe toxicity, manifested as coma, occurs at lower blood alcohol concentrations …

Effect of alcohol on Glasgow Coma Scale in head-injured patients

L Stuke, R Diaz-Arrastia, LM Gentilello… - Annals of surgery, 2007 - journals.lww.com
Objective: Almost 50% of traumatic brain-injured (TBI) patients are alcohol intoxicated. The
Glasgow Coma Scale (GCS) is frequently used to direct diagnostic and therapeutic …

Induction of cyclooxygenase‐2 in brain during acute and chronic ethanol treatment and ethanol withdrawal

DJ Knapp, FT Crews - Alcoholism: Clinical and Experimental …, 1999 - Wiley Online Library
Prostaglandins play an important role in the regulation of nervous system function including
thermoregulation, autonomic nervous system function, hypothalamic regulation of pituitary …

Distinct cell proliferation events during abstinence after alcohol dependence: microglia proliferation precedes neurogenesis

K Nixon, DH Kim, EN Potts, J He, FT Crews - Neurobiology of disease, 2008 - Elsevier
Excessive alcohol intake characteristic of Alcohol Use Disorders (AUDs) produces
neurodegeneration that may recover with abstinence. The mechanism of regeneration is …

Alcohol-induced apoptosis of oligodendrocytes in the fetal macaque brain

CE Creeley, KT Dikranian, SA Johnson… - Acta neuropathologica …, 2013 - Springer
Background In utero exposure of the fetal non-human primate (NHP) brain to alcohol on a
single occasion during early or late third-trimester gestation triggers widespread acute …

Alcohol-induced neuroapoptosis in the fetal macaque brain

NB Farber, CE Creeley, JW Olney - Neurobiology of disease, 2010 - Elsevier
The ability of brief exposure to alcohol to cause widespread neuroapoptosis in the
developing rodent brain and subsequent long-term neurocognitive deficits has been …

Comparison of blood-ethanol concentration in deaths attributed to acute alcohol poisoning and chronic alcoholism

AW Jones, P Holmgren - Journal of Forensic Sciences, 2003 - astm.org
Ethanol concentrations were measured in femoral venous blood in deaths attributed to acute
alcohol poisoning (N= 693) or chronic alcoholism (N= 825), according to the forensic …

Waiting for the patient to “sober up”: Effect of alcohol intoxication on glasgow coma scale score of brain injured patients

JL Sperry, LM Gentilello, JP Minei… - Journal of Trauma …, 2006 - journals.lww.com
Background: Between 35% to 50% of traumatic brain injury (TBI) patients are under the
influence of alcohol. Alcohol intoxication may limit the ability of the Glasgow Coma Scale …