Genetics of human primary hypertension: focus on hormonal mechanisms

W Manosroi, GH Williams - Endocrine reviews, 2019 - academic.oup.com
Increasingly, primary hypertension is being considered a syndrome and not a disease, with
the individual causes (diseases) having a common sign—an elevated blood pressure. To …

Microalbuminuria in essential hypertension: significance, pathophysiology, and therapeutic implications

S Bianchi, R Bigazzi, VM Campese - American journal of kidney diseases, 1999 - Elsevier
Some patients with essential hypertension manifest greater than normal urinary albumin
excretion (UAE). The significance of this association, which is the object of this review, is not …

Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension.

MO Ribeiro, E Antunes, G De Nucci, SM Lovisolo… - …, 1992 - Am Heart Assoc
Recent studies have indicated that acute inhibition of nitric oxide biosynthesis in the rat
promotes arterial hypertension and renal vasoconstriction. We evaluated the renal and …

Natriuretic peptides in vascular physiology and pathology

GE Woodard, JA Rosado - International review of cell and molecular …, 2008 - Elsevier
Four major natriuretic peptides have been isolated: atrial natriuretic peptide (ANP), brain
natriuretic peptide (BNP), C‐type natriuretic peptide (CNP), and Dendroaspis‐type …

[HTML][HTML] Pulse pressure and isolated systolic hypertension: association with microalbuminuria

M Cirillo, D Stellato, M Laurenzi, W Panarelli… - Kidney international, 2000 - Elsevier
Pulse pressure and isolated systolic hypertension: Association with microalbuminuria.
Background The long-term risk of end-stage renal disease is high in persons with isolated …

Reduction of blood pressure with oral magnesium supplementation in women with mild to moderate hypertension

JC Witteman, DE Grobbee, FH Derkx, R Bouillon… - The American journal of …, 1994 - Elsevier
In a double-blind controlled trial. 91 middle-aged and elderly women with mild to moderate
hypertension who were not on antihypertensive medication were randomly assigned to …

[HTML][HTML] α-Adducin polymorphisms and renal sodium handling in essential hypertensive patients

P Manunta, D Cusi, C Barlassina, M Righetti… - Kidney international, 1998 - Elsevier
α-Adducin polymorphisms and renal sodium handling in essential hypertensive patients.
The relationship between blood pressure and sodium (Na) excretion is less steep in …

Genetic determinants of hypertension: identification of candidate phenotypes

TA Kotchen, JM Kotchen, CE Grim, V George… - …, 2000 - Am Heart Assoc
Our long-term objective is to identify genes whose expression results in hypertension and in
phenotypic changes that may contribute to hypertension. The purpose of the present study …

Early narrowed afferent arteriole is a contributor to the development of hypertension.

H Nørrelund, KL Christensen, NJ Samani, P Kimber… - …, 1994 - Am Heart Assoc
The kidney is probably critically involved in the development of essential hypertension, as in
many genetic models of hypertension. We have investigated whether a narrowed renal …

The kidney in blood pressure regulation and development of hypertension

LG Navar - Medical Clinics, 1997 - medical.theclinics.com
Various neural, hormonal, and hemodynamic mechanisms interact to achieve efficient
regulation of arterial pressure by responding to different extrinsic disturbances capable of …