Lipid nanoparticles (LNPs) have shown promise as delivery vehicles for therapeutic
oligonucleotides, including antisense oligos (ONs), siRNA, and microRNA mimics and …

RNA interference (RNAi) targeting lethal genes in insects has great potential for sustainable
crop protection. Compared with traditional double‐stranded (ds) RNA delivery systems …

HER2 is highly expressed in a significant proportion of breast cancer, ovarian cancer, and
gastric cancer. Since the discovery of its role in tumorigenesis, HER2 has received great …

RNA interference (RNAi) uses small interfering RNAs (siRNAs) to mediate gene-silencing in
cells and represents an emerging strategy for cancer therapy. Successful RNAi-mediated …

Nanocarriers as drug delivery systems are promising and becoming popular, especially for
cancer treatment. In addition to improving the pharmacokinetics of poorly soluble …

Abstract Lipid-based colloidal particles have been extensively studied as systemic gene
delivery carriers. The topic that we would like to emphasize is the formulation/assembly of …

Since the discovery of the Nobel prize-winning mechanism of RNA interference (RNAi) ten
years ago, it has become a promising drug target for the treatment of multiple diseases …

RNAi technology has brought a new category of treatments for various diseases including
genetic diseases, viral diseases, and cancer. Despite the great versatility of RNAi that can …

Solid lipid nanoparticles (SLNs) have been proposed in the 1990s as appropriate drug
delivery systems, and ever since they have been applied in a wide variety of cosmetic and …

The preparation of protein single crystals represents one of the major obstacles in obtaining
the detailed 3D structure of a biological macromolecule. The complete automation of the …