[HTML][HTML] Cyclin E/CDK2: DNA replication, replication stress and genomic instability
R Fagundes, LK Teixeira - Frontiers in cell and developmental biology, 2021 - frontiersin.org
DNA replication must be precisely controlled in order to maintain genome stability.
Transition through cell cycle phases is regulated by a family of Cyclin-Dependent Kinases …
Transition through cell cycle phases is regulated by a family of Cyclin-Dependent Kinases …
Mechanisms of PTEN loss in cancer: It's all about diversity
V Álvarez-Garcia, Y Tawil, HM Wise… - Seminars in cancer biology, 2019 - Elsevier
PTEN is a phosphatase which metabolises PIP 3, the lipid product of PI 3-Kinase, directly
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …
[HTML][HTML] Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
The discovery of drivers of cancer has traditionally focused on protein-coding genes,,–. Here
we present analyses of driver point mutations and structural variants in non-coding regions …
we present analyses of driver point mutations and structural variants in non-coding regions …
[HTML][HTML] Genomic hallmarks and structural variation in metastatic prostate cancer
While mutations affecting protein-coding regions have been examined across many
cancers, structural variants at the genome-wide level are still poorly defined. Through …
cancers, structural variants at the genome-wide level are still poorly defined. Through …
[HTML][HTML] Distinct classes of complex structural variation uncovered across thousands of cancer genome graphs
Cancer genomes often harbor hundreds of somatic DNA rearrangement junctions, many of
which cannot be easily classified into simple (eg, deletion) or complex (eg, chromothripsis) …
which cannot be easily classified into simple (eg, deletion) or complex (eg, chromothripsis) …
[HTML][HTML] Comparative molecular analysis of gastrointestinal adenocarcinomas
We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to
examine shared and distinguishing molecular characteristics of gastrointestinal tract …
examine shared and distinguishing molecular characteristics of gastrointestinal tract …
Genome-wide detection of tandem DNA repeats that are expanded in autism
B Trost, W Engchuan, CM Nguyen… - Nature, 2020 - nature.com
Tandem DNA repeats vary in the size and sequence of each unit (motif). When expanded,
these tandem DNA repeats have been associated with more than 40 monogenic disorders …
these tandem DNA repeats have been associated with more than 40 monogenic disorders …
Prediction of DNA repair inhibitor response in short-term patient-derived ovarian cancer organoids
Based on genomic analysis, 50% of high-grade serous ovarian cancers (HGSC) are
predicted to have DNA repair defects. Whether this substantial subset of HGSCs actually …
predicted to have DNA repair defects. Whether this substantial subset of HGSCs actually …
[HTML][HTML] The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes
The genomic landscape of breast cancer is complex, and inter-and intra-tumour
heterogeneity are important challenges in treating the disease. In this study, we sequence …
heterogeneity are important challenges in treating the disease. In this study, we sequence …
[HTML][HTML] A CRISPR dropout screen identifies genetic vulnerabilities and therapeutic targets in acute myeloid leukemia
Acute myeloid leukemia (AML) is an aggressive cancer with a poor prognosis, for which
mainstream treatments have not changed for decades. To identify additional therapeutic …
mainstream treatments have not changed for decades. To identify additional therapeutic …