Mistakes during cell division frequently generate changes in chromosome content,
producing aneuploid or polyploid progeny cells. Polyploid cells may then undergo abnormal …

Activation of nuclear factor (NF)-κB, one of the most investigated transcription factors, has
been found to control multiple cellular processes in cancer including inflammation …

Increasingly, human mesenchymal malignancies are being classified by the abnormalities
that drive their pathogenesis. Although many of these aberrations are highly prevalent within …

Recent advances in next-generation sequencing technologies have brought a paradigm
shift in how medical researchers investigate both rare and common human disorders. The …

There has been much progress in genomics in the ten years since a draft sequence of the
human genome was published. Opportunities for understanding health and disease are now …

Tissues are three‐dimensional (3D) entities as is the tumor that arises within them. Though
disaggregated cancerous tissues have produced numerous cell lines for basic and applied …

Copy number variation (CNV) is increasingly recognized as an important contributor to
phenotypic variation in health and disease. Most methods for determining CNV rely on …

DNA double-strand breaks (DSBs) in B lymphocytes arise stochastically during replication or
as a result of targeted DNA damage by activation-induced cytidine deaminase (AID). Here …

Inactivation of tumour-suppressor genes by homozygous deletion is a prototypic event in the
cancer genome, yet such deletions often encompass neighbouring genes. We propose that …

Cyclins A2 and E1 regulate the cell cycle by promoting S phase entry and progression.
Here, we identify a hepatocellular carcinoma (HCC) subgroup exhibiting cyclin activation …