Tumour-associated macrophages are an essential component of the tumour
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …

Many of the ligands for Toll-like receptors (TLRs) are unique to microorganisms, such that
receptor activation unequivocally indicates the presence of something foreign. However, a …

Purpose: This phase I study assessed the safety, pharmacokinetics (PKs), and efficacy of
MIW815 (ADU-S100), a novel synthetic cyclic dinucleotide that activates the stimulator of IFN …

Natural killer (NK) cells are cytotoxic innate lymphocytes that eradicate tumor cells. Inducing
durable antitumor immune responses by NK cells represents a major priority of cancer …

Myeloid cells infiltrating tumors are gaining ever growing attention in the last years because
their pro-tumor and immunosuppressive functions are relevant for disease progression and …

DNA walkers, a sophisticated type of nanomachines, exhibit intelligent application in
biosensing with high programmability and flexibility but usually need additional auxiliary …

Mitochondrial antiviral signaling protein (MAVS)–mediated cytosolic RNA sensing plays a
central role in tumor immunogenicity. However, the effects of host MAVS signaling on …

Cyclic dinucleotides (CDN) and Toll-like receptor (TLR) ligands mobilize antitumor
responses by natural killer (NK) cells and T cells, potentially serving as complementary …

Chemotherapy resistance is one of the most critical challenges in colorectal cancer (CRC)
treatment. The occurrence and development of chemotherapy resistance closely related to …

Nucleic acid sensing is involved in viral infections, immune response-related diseases, and
therapeutics. Based on the composition of nucleic acids, nucleic acid sensors are defined as …