Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases
The extracellular matrix (ECM) is a complex network of macromolecules surrounding cells
providing structural support and stability to tissues. The understanding of the ECM and the …
providing structural support and stability to tissues. The understanding of the ECM and the …
Engineering DNA vaccines against infectious diseases
Engineering vaccine-based therapeutics for infectious diseases is highly challenging, as
trial formulations are often found to be nonspecific, ineffective, thermally or hydrolytically …
trial formulations are often found to be nonspecific, ineffective, thermally or hydrolytically …
Supersulphides provide airway protection in viral and chronic lung diseases
T Matsunaga, H Sano, K Takita, M Morita… - Nature …, 2023 - nature.com
Supersulphides are inorganic and organic sulphides with sulphur catenation with diverse
physiological functions. Their synthesis is mainly mediated by mitochondrial cysteinyl-tRNA …
physiological functions. Their synthesis is mainly mediated by mitochondrial cysteinyl-tRNA …
Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis
Accumulating evidence illustrates a fundamental role for mitochondria in lung alveolar type
2 epithelial cell (AEC2) dysfunction in the pathogenesis of idiopathic pulmonary fibrosis …
2 epithelial cell (AEC2) dysfunction in the pathogenesis of idiopathic pulmonary fibrosis …
CSF1R inhibition prevents radiation pulmonary fibrosis by depletion of interstitial macrophages
Radiation-induced lung fibrosis (RIF) is a delayed side-effect of chest radiotherapy,
frequently associated with macrophage infiltration. We aimed to characterise the role of …
frequently associated with macrophage infiltration. We aimed to characterise the role of …
The aged extracellular matrix and the profibrotic role of senescence-associated secretory phenotype
Idiopathic pulmonary fibrosis (IPF) is an irreversible and fatal lung disease that is primarily
found in the elderly population, and several studies have demonstrated that aging is the …
found in the elderly population, and several studies have demonstrated that aging is the …
De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8
Abstract The RGD (Arg-Gly-Asp)-binding integrins αvβ6 and αvβ8 are clinically validated
cancer and fibrosis targets of considerable therapeutic importance. Compounds that can …
cancer and fibrosis targets of considerable therapeutic importance. Compounds that can …
Quantitative image analysis for tissue biomarker use: a white paper from the digital pathology association
Tissue biomarkers have been of increasing utility for scientific research, diagnosing disease,
and treatment response prediction. There has been a steady shift away from qualitative …
and treatment response prediction. There has been a steady shift away from qualitative …
Elevation of IL‐6 and IL‐33 levels in serum associated with lung fibrosis and skeletal muscle wasting in a bleomycin‐induced lung injury mouse model
JM Shieh, HY Tseng, F Jung, SH Yang… - Mediators of …, 2019 - Wiley Online Library
Weight loss due to skeletal muscle atrophy in patients with chronic pulmonary disease is
negatively correlated with clinical outcome. Pulmonary fibrosis is a chronic and progressive …
negatively correlated with clinical outcome. Pulmonary fibrosis is a chronic and progressive …
[HTML][HTML] Artificial intelligence identifies inflammation and confirms fibroblast foci as prognostic tissue biomarkers in idiopathic pulmonary fibrosis
K Mäkelä, MI Mäyränpää, HK Sihvo, P Bergman… - Human Pathology, 2021 - Elsevier
A large number of fibroblast foci (FF) predict mortality in idiopathic pulmonary fibrosis (IPF).
Other prognostic histological markers have not been identified. Artificial intelligence (AI) …
Other prognostic histological markers have not been identified. Artificial intelligence (AI) …