Pulmonary arterial smooth muscle cell (PASMC) phenotype switching, which is
characterized by changes in smooth muscle (SM)-specific gene expression, contributes to …

Pulmonary hypertension (PH) is a common in patients with idiopathic pulmonary fibrosis
(IPF) referred for transplantation. When present, PH is associated with increased mortality …

How two-chambered hearts in basal vertebrates have evolved from single-chamber hearts
found in ancestral chordates remains unclear. Here, we show that the teleost sinus venosus …

BACKGROUND: Sildenafil (phosphodiesterase type 5 inhibitor) has been shown to be
effective in pulmonary arterial hypertension (PAH). We evaluated the efficacy and safety of …

Pulmonary hypertension (PH) is a progressive disorder characterized by alterations of the
vascular structure and function in the lungs. Despite the success in its stabilisation by …

Idiopathic pulmonary arterial hypertension (IPAH) is associated with lower levels of the
pulmonary vasodilator nitric oxide (NO) and its biochemical reaction products (nitrite [NO2−] …

Chronic hypoxia activates transforming growth factor-β (TGF-β) signaling and leads to
pulmonary vascular remodeling. Pharmacological activation of peroxisome proliferator …

Cardiovascular diseases (CVD) are the leading cause of death worldwide. CVD comprise a
range of diseases affecting the functionality of the heart and blood vessels, including acute …

OBJECTIVE: Transposition of the great arteries is currently treated by performing the arterial
switch operation. Dilatation of the neoaortic root is a late complication with unknown cause …

Pulmonary arterial hypertension (PAH) is a progressive and debilitating condition. Despite
promoting vasodilation, current drugs have a therapeutic window within which they are …