The physiological effects of the endogenously generated hydrogen sulfide (H 2 S) have
been extensively studied in recent years. This review summarized the role of H 2 S in the …

Pulmonary arterial hypertension is a disease of the small pulmonary arteries characterized
by vascular narrowing and increased pulmonary vascular resistance, which eventually leads …

The proliferation and apoptosis of pulmonary artery smooth muscle cells (PASMCs) are
considered to be key steps in the progression of pulmonary arterial hypertension (PAH) …

Prostacyclin therapy has transformed the care of patients with pulmonary arterial
hypertension (PAH), an orphan disease for which there was no effective treatment option for …

Chronic hypoxia-induced pulmonary hypertension results partly from proliferation of smooth
muscle cells in small peripheral pulmonary arteries. Previously, we demonstrated that …

Hypoxia-induced pulmonary hypertension (PH), which is characterized by vascular
remodeling of blood vessels, is a significant complication of chronic obstructive pulmonary …

Pulmonary arterial hypertension (PAH) is a rare and lethal disease characterized by
vascular remodeling and vasoconstriction, which is associated with increased intracellular …

Considerable evidence demonstrates that phenotypic switching of vascular smooth muscle
cells (VSMCs) is influenced by aging and hypertension. During phenotypic switching …

Left heart diseases (LHD) represent the most prevalent cause of pulmonary hypertension
(PH), yet there are still no approved therapies that selectively target the pulmonary …

Chronic hypoxia during gestation induces greater occurrence of perinatal complications
such as intrauterine growth restriction, fetal hypoxia, newborn asphyxia, and respiratory …