In the last decades, the conceptualization of schizophrenia has dramatically changed,
moving from a neurodegenerative process occurring in early adult life to a …

Schizophrenia is a heritable neurocognitive disorder affecting about 1% of the population,
and usually has an onset age at around 21–25 in males and 25–30 in females. Recent …

Background: Schizophrenia is a complex mental disorder with a high heritability.
Dysfunction of the N-methyl-D-aspartate (NMDA)-type glutamate receptors may be involved …

Psychosis is a cluster of symptoms that involve difficulties knowing what is real and what is
not real. As with any mental health experience, psychosis can be seen as a spectrum of …

To assess the role of age (early onset psychosis-EOP< 18 years vs. adult onset psychosis-
AOP) and diagnosis (schizophrenia spectrum disorders-SSD vs. bipolar disorders-BD) on …

Background Low-grade inflammation has been implicated in the pathophysiology of severe
mental disorders (SMDs) and a link between immune activation and clinical characteristics …

Background Very early-onset schizophrenia (VEOS) is a form of schizophrenia that
manifests before the age of 13 years and is characterized by the presence of positive …

Based on the assumption of a universal neurodevelopmental model of psychosis, especially
of the schizophrenia spectrum, the diagnosis (and treatment) of psychosis in minors …

Early-onset psychosis is linked to adverse long-term outcomes, recurrent disease course,
and prolonged periods of untreated illness; thus highlighting the urgency of improving early …

Approximately 8% of patients with schizophrenia are diagnosed before age 18, and 18%
experience their first symptoms before age 18. This narrative review explores the …