Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation
Precise spatio–temporal control of gene activity is essential for organismal development,
growth, and survival in a changing environment. Decisive steps in gene regulation involve …
growth, and survival in a changing environment. Decisive steps in gene regulation involve …
Eukaryotic cell size control and its relation to biosynthesis and senescence
The most fundamental feature of cellular form is size, which sets the scale of all cell
biological processes. Growth, form, and function are all necessarily linked in cell biology, but …
biological processes. Growth, form, and function are all necessarily linked in cell biology, but …
Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation
Abstract Cyclin-dependent kinase 9 (CDK9), an important regulator of transcriptional
elongation, is a promising target for cancer therapy, particularly for cancers driven by …
elongation, is a promising target for cancer therapy, particularly for cancers driven by …
The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain
KM Harlen, LS Churchman - Nature reviews Molecular cell biology, 2017 - nature.com
The carboxy-terminal domain (CTD) extends from the largest subunit of RNA polymerase II
(Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the …
(Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the …
SAGA is a general cofactor for RNA polymerase II transcription
T Baptista, S Grünberg, N Minoungou, MJE Koster… - Molecular cell, 2017 - cell.com
Prior studies suggested that SAGA and TFIID are alternative factors that promote RNA
polymerase II transcription, with about 10% of genes in S. cerevisiae dependent on SAGA …
polymerase II transcription, with about 10% of genes in S. cerevisiae dependent on SAGA …
G1 cyclin–Cdk promotes cell cycle entry through localized phosphorylation of RNA polymerase II
Cell division is thought to be initiated by cyclin-dependent kinases (Cdks) inactivating key
transcriptional inhibitors. In budding yeast, the G1 cyclin Cln3-Cdk1 complex is thought to …
transcriptional inhibitors. In budding yeast, the G1 cyclin Cln3-Cdk1 complex is thought to …
RNA polymerase II dynamics and mRNA stability feedback scale mRNA amounts with cell size
MP Swaffer, GK Marinov, H Zheng, LF Valenzuela… - Cell, 2023 - cell.com
A fundamental feature of cellular growth is that total protein and RNA amounts increase with
cell size to keep concentrations approximately constant. A key component of this is that …
cell size to keep concentrations approximately constant. A key component of this is that …
Spatiotemporal coordination of transcription preinitiation complex assembly in live cells
Transcription initiation by RNA polymerase II (RNA Pol II) requires preinitiation complex
(PIC) assembly at gene promoters. In the dynamic nucleus, where thousands of promoters …
(PIC) assembly at gene promoters. In the dynamic nucleus, where thousands of promoters …
Development of a selective CDK7 covalent inhibitor reveals predominant cell-cycle phenotype
CM Olson, Y Liang, A Leggett, WD Park, L Li… - Cell chemical …, 2019 - cell.com
Summary Cyclin-dependent kinase 7 (CDK7) regulates both cell cycle and transcription, but
its precise role remains elusive. We previously described THZ1, a CDK7 inhibitor, which …
its precise role remains elusive. We previously described THZ1, a CDK7 inhibitor, which …
Cdk7: a kinase at the core of transcription and in the crosshairs of cancer drug discovery
RP Fisher - Transcription, 2019 - Taylor & Francis
The transcription cycle of RNA polymerase II (Pol II) is regulated by a set of cyclin-dependent
kinases (CDKs). Cdk7, associated with the transcription initiation factor TFIIH, is both an …
kinases (CDKs). Cdk7, associated with the transcription initiation factor TFIIH, is both an …