Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies

BL Edlow, J Claassen, ND Schiff… - Nature Reviews Neurology, 2021 - nature.com
Substantial progress has been made over the past two decades in detecting, predicting and
promoting recovery of consciousness in patients with disorders of consciousness (DoC) …

Medical management of the severe traumatic brain injury patient

J Marehbian, S Muehlschlegel, BL Edlow, HE Hinson… - Neurocritical care, 2017 - Springer
Severe traumatic brain injury (sTBI) is a major contributor to long-term disability and a
leading cause of death worldwide. Medical management of the sTBI patient, beginning with …

A precision medicine framework for classifying patients with disorders of consciousness: Advanced Classification of Consciousness Endotypes (ACCESS)

D Kondziella, DK Menon, R Helbok, L Naccache… - Neurocritical Care, 2021 - Springer
Background Consciousness in patients with brain injury is traditionally assessed based on
semiological evaluation at the bedside. This classification is limited because of low …

Favorable functional recovery in severe traumatic brain injury survivors beyond six months

TE Wilkins, SR Beers, AJ Borrasso, J Brooks… - Journal of …, 2019 - liebertpub.com
Favorable long-term functional outcomes after severe traumatic brain injury (TBI) may be
underestimated. We analyzed 24-month functional outcomes from a consecutive series of …

Progesterone neuroprotection: the background of clinical trial failure

M Schumacher, C Denier, JP Oudinet, D Adams… - The Journal of steroid …, 2016 - Elsevier
Since the first pioneering studies in the 1990s, a large number of experimental animal
studies have demonstrated the neuroprotective efficacy of progesterone for brain disorders …

Assessment of covert consciousness in the intensive care unit: clinical and ethical considerations

BL Edlow, JJ Fins - The Journal of head trauma rehabilitation, 2018 - journals.lww.com
Objective: To propose a practical ethical framework for how task-based functional magnetic
resonance imaging (fMRI) and electroencephalography (EEG) may be used in the intensive …

[图书][B] The ethics of uncertainty: entangled ethical and epistemic risks in disorders of consciousness

LSM Johnson - 2022 - books.google.com
Disorders of Consciousness (DoCs) raise difficult and complex questions about the value of
life for persons with impaired consciousness, the rights of persons unable to make medical …

Ethical considerations and fairness in the use of artificial intelligence for neuroradiology

CG Filippi, JM Stein, Z Wang, S Bakas… - American Journal …, 2023 - Am Soc Neuroradiology
In this review, concepts of algorithmic bias and fairness are defined qualitatively and
mathematically. Illustrative examples are given of what can go wrong when unintended bias …

Understanding, detecting, and stimulating consciousness recovery in the ICU

D Kondziella, M Amiri, MH Othman, EW Jakobsen… - Acta …, 2023 - Springer
Coma is a medical and socioeconomic emergency. Although underfunded, research on
coma and disorders of consciousness has made impressive progress. Lesion-network …

Multimodal approaches supporting the diagnosis, prognosis and investigation of neural correlates of disorders of consciousness: A systematic review

A Gallucci, E Varoli, L Del Mauro… - European Journal of …, 2024 - Wiley Online Library
The limits of the standard, behaviour‐based clinical assessment of patients with disorders of
consciousness (DoC) prompted the employment of functional neuroimaging …