Challenges of neuropathic pain: focus on diabetic neuropathy

DC Rosenberger, V Blechschmidt… - Journal of Neural …, 2020 - Springer
Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …

A comprehensive algorithm for management of neuropathic pain

D Bates, BC Schultheis, MC Hanes, SM Jolly… - Pain …, 2019 - academic.oup.com
Background The objective of this review was to merge current treatment guidelines and best
practice recommendations for management of neuropathic pain into a comprehensive …

Therapeutic approaches for peripheral and central neuropathic pain

D Szok, J Tajti, A Nyári, L Vécsei - Behavioural neurology, 2019 - Wiley Online Library
Neuropathic pain is a chronic secondary pain condition, which is a consequence of
peripheral or central nervous (somatosensory) system lesions or diseases. It is a devastating …

Regulatory T cells counteract neuropathic pain through inhibition of the Th1 response at the site of peripheral nerve injury

M Davoli-Ferreira, KA de Lima, MM Fonseca… - Pain, 2020 - journals.lww.com
The inflammatory/immune response at the site of peripheral nerve injury participates in the
pathophysiology of neuropathic pain. Nevertheless, little is known about the local regulatory …

Natural antioxidant control of neuropathic pain—exploring the role of mitochondrial sirt3 pathway

S Ilari, LA Giancotti, F Lauro, M Gliozzi, V Malafoglia… - Antioxidants, 2020 - mdpi.com
Neuropathic pain is a chronic painful disease. Data have shown that reactive oxygen
species (ROS) are implicated in chronic pain. Particularly, the enhanced ROS production …

Effectiveness and tolerability of THC: CBD oromucosal spray as add-on measure in patients with severe chronic pain: analysis of 12-week open-label real-world data …

MA Ueberall, U Essner… - Journal of Pain …, 2019 - Taylor & Francis
Objective: To evaluate effectiveness, tolerability and safety of an oromucosal spray
containing Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), as add-on treatment in …

[HTML][HTML] Neuropathic pain in neurologic disorders: a narrative review

DD Mitsikostas, E Moka, E Orrillo, C Aurilio… - Cureus, 2022 - ncbi.nlm.nih.gov
Neuropathic pain is defined as a painful condition caused by neurological lesions or
diseases. Sometimes, neurological disorders may also be associated with neuropathic pain …

Effect of glucoraphanin and sulforaphane against chemotherapy‐induced neuropathic pain: Kv7 potassium channels modulation by H2S release in vivo

E Lucarini, L Micheli, E Trallori, V Citi… - Phytotherapy …, 2018 - Wiley Online Library
The beneficial effects of isothiocyanate‐based compounds, as well as their safety, have
been shown in neuropathological disorders, such as neuropathic pain. Aim of the present …

Guidelines for the diagnosis and treatment of neuroangiostrongyliasis: updated recommendations

V Ansdell, KJ Kramer, JK McMillan, WL Gosnell… - Parasitology, 2021 - cambridge.org
A subcommittee of the Hawaii Governor's Joint Task Force on Rat Lungworm Disease
developed preliminary guidelines for the diagnosis and treatment of neuroangiostrongyliasis …

Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one …

S Intagliata, A Sharma, TI King, C Mesangeau… - The AAPS Journal, 2020 - Springer
The sigma-2 receptor has been cloned and identified as Tmem97, which is a
transmembrane protein involved in intracellular Ca 2+ regulation and cholesterol …