Potential neuroprotective treatment of stroke: targeting excitotoxicity, oxidative stress, and inflammation

Q Yang, Q Huang, Z Hu, X Tang - Frontiers in neuroscience, 2019 - frontiersin.org
Stroke is a major cause of death and adult disability. However, therapeutic options remain
limited. Numerous pathways underlie acute responses of brain tissue to stroke. Early events …

Novel interventions to reduce oxidative-stress related brain injury in neonatal asphyxia

AL Solevåg, GM Schmölzer, PY Cheung - Free Radical Biology and …, 2019 - Elsevier
Perinatal asphyxia-induced brain injury may present as hypoxic-ischemic encephalopathy in
the neonatal period, and disability including cerebral palsy in the long term. The brain injury …

Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation

Y Koike, B Li, N Ganji, H Zhu, H Miyake, Y Chen… - Nature …, 2020 - nature.com
Necrotizing enterocolitis (NEC) is a devastating disease of premature infants with high
mortality rate, indicating the need for precision treatment. NEC is characterized by intestinal …

Neural mechanisms in remote ischaemic conditioning in the heart and brain: mechanistic and translational aspects

MV Basalay, SM Davidson, AV Gourine… - Basic research in …, 2018 - Springer
Remote ischaemic conditioning (RIC) is a promising method of cardioprotection, with
numerous clinical studies having demonstrated its ability to reduce myocardial infarct size …

Improving the ischemia-reperfusion injury in vascularized composite allotransplantation: Clinical experience and experimental implications

J He, UZ Khan, L Qing, P Wu, J Tang - Frontiers in Immunology, 2022 - frontiersin.org
Long-time ischemia worsening transplant outcomes in vascularized composite
allotransplantation (VCA) is often neglected. Ischemia-reperfusion injury (IRI) is an …

Remote ischemic conditioning as an additional treatment for acute ischemic stroke: the preclinical and clinical evidence

TRJ Landman, Y Schoon, MC Warlé, FE de Leeuw… - Stroke, 2019 - Am Heart Assoc
Methods A formal systematic review was not performed because of the heterogeneity of the
studies and recently published systematic reviews on preclinical 12 and clinical studies. 13 …

Cerebral protection by remote ischemic post-conditioning in patients with ischemic stroke: a systematic review and meta-analysis of randomized controlled trials

M Lu, Y Wang, X Yin, Y Li, H Li - Frontiers in Neurology, 2022 - frontiersin.org
Background There is evidence that remote limb ischemic postconditioning (RIPostC) can
reduce ischemia-reperfusion injury (IRI) and improve the prognosis of patients with ischemic …

Remote ischemic conditioning in ischemic stroke and myocardial infarction: similarities and differences

LF Saccaro, A Aimo, M Emdin, F Pico - Frontiers in Neurology, 2021 - frontiersin.org
Acute myocardial infarction and ischemic stroke are leading causes of morbidity and
mortality worldwide. Although reperfusion therapies have greatly improved the outcomes of …

Neuroprotective Effects of Exercise Postconditioning After Stroke via SIRT1-Mediated Suppression of Endoplasmic Reticulum (ER) Stress

F Li, X Geng, H Lee, M Wills, Y Ding - Frontiers in Cellular …, 2021 - frontiersin.org
While it is well-known that pre-stroke exercise conditioning reduces the incidence of stroke
and the development of comorbidities, it is unclear whether post-stroke exercise …

Remote ischemic conditioning in necrotizing enterocolitis: study protocol of a multi-center phase II feasibility randomized controlled trial

N Ganji, B Li, I Ahmad, A Daneman… - Pediatric surgery …, 2022 - Springer
Purpose Remote ischemic conditioning (RIC) is a maneuver involving brief cycles of
ischemia reperfusion in an individual's limb. In the early stage of experimental NEC, RIC …