Alcohol Use Disorder Treatment: Problems and Solutions

GF Koob - Annual Review of Pharmacology and Toxicology, 2024 - annualreviews.org
Alcohol use disorder (AUD) afflicts over 29 million individuals and causes more than
140,000 deaths annually in the United States. A heuristic framework for AUD includes a …

Initiation of and escalation to high-intensity drinking in young adults

ME Patrick, RJ Evans-Polce, BJ Arterberry… - JAMA …, 2023 - jamanetwork.com
Importance High-intensity drinking (HID)(≥ 10 drinks in a row) is associated with acute
negative outcomes. Identifying factors associated with HID initiation in adolescence and how …

The Heterogenous Nature of Substance Use and Substance Use Disorders: Implications for Characterizing Substance-Related Stigma

KJ Sher - Psychological Science in the Public Interest, 2023 - journals.sagepub.com
Krendl and Perry's article is titled “Stigma Toward Substance Dependence: Causes,
Consequences, and Potential Interventions,” but most of the article focuses not on substance …

Why haven't we solved the addiction crisis?

K Blum, A Bowirrat, LL Gomez, BW Downs… - Journal of the …, 2022 - Elsevier
The current addiction crisis has destroyed a multitude of lives, leaving millions of fatalities
worldwide in its wake. At the same time, various governmental agencies dedicated to …

Does polygenic risk for substance‐related traits predict ages of onset and progression of symptoms?

HR Kranzler, R Feinn, H Xu, BL Ho, D Saini… - …, 2023 - Wiley Online Library
Abstract Background and Aims Genetic risk can influence disease progression. We
measured the impact of genetic risk for substance use disorders (SUDs) on substance use …

[HTML][HTML] Summary document research on RDS anti-addiction modeling: annotated bibliography

K Blum, D Baron, T McLaughlin… - Journal of addiction …, 2024 - ncbi.nlm.nih.gov
Annotated bibliography of genetic addiction risk severity (GARS) publications, pro-dopamine
regulation in nutraceuticals (KB220 nutraceutical variants), and policy documents. Further …

[HTML][HTML] Genetic Addiction risk and psychological profiling analyses for “Preaddiction” Severity Index

K Blum, D Han, A Bowirrat, BW Downs… - Journal of Personalized …, 2022 - mdpi.com
Since 1990, when our laboratory published the association of the DRD2 Taq A1 allele and
severe alcoholism in JAMA, there has been an explosion of genetic candidate association …

[HTML][HTML] The Craving-Manager smartphone app designed to diagnose substance use/addictive disorders, and manage craving and individual predictors of relapse: a …

F Serre, S Moriceau, L Donnadieu, C Forcier… - Frontiers in …, 2023 - frontiersin.org
Background The rate of individuals with addiction who are currently treated are low, and this
can be explained by barriers such as stigma, desire to cope alone, and difficulty to access …

Diagnostic Criteria for Identifying Individuals at High Risk of Progression From Mild or Moderate to Severe Alcohol Use Disorder

AP Miller, I Sally, C Kuo, EC Johnson… - JAMA network …, 2023 - jamanetwork.com
Importance CurrentDiagnostic and Statistical Manual of Mental Disorders (Fifth
Edition)(DSM-5) diagnoses of substance use disorders rely on criterion count–based …

Social media interventions addressing physical activity among emerging adults who use cannabis: A pilot trial of feasibility and acceptability

EE Bonar, L Chapman, S Pagoto, CY Tan… - Drug and Alcohol …, 2023 - Elsevier
Purpose Cannabis use is common among emerging adults (ages 18–25), yet few prevention
interventions have targeted this unique developmental period. Physical activity (PA) is an …