The role of genetic and epigenetic factors in tumor initiation and progression is well
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …

Purpose In this review, we highlight the current concepts and discuss some of the current
challenges and future prospects in cancer therapy. We frequently use the example of lung …

Ferroptosis, a novel form of programmed cell death, is characterized by iron-dependent lipid
peroxidation and has been shown to be involved in multiple diseases, including cancer …

Background Lung cancer is the leading cancer diagnosis worldwide and the number one
cause of cancer deaths. Exposure to cigarette smoke, the primary risk factor in lung cancer …

Simple Summary Lung adenocarcinoma (LUAD) is the major subtype of lung cancer and
represents the deadliest human cancer, affecting current-, ex-, and even non-smokers …

Background Lung cancer is the leading cause of cancer-related deaths worldwide (Ferlay et
al., Int J Cancer 136: E359–386, 2015). In addition, lung cancer is associated with the …

CD8+ T lymphocytes are the major anti-tumor effector cells. Most cancer immunotherapeutic
approaches seek to amplify cytotoxic T lymphocytes (CTL) specific to malignant cells. A …

Abstract Treatment of lung cancer remains a challenge, and lung cancer is still the leading
cause of cancer‐related mortality. Immunotherapy has previously failed in lung cancer but …

Non-small-cell lung cancer is one of the leading causes of deaths from cancer worldwide.
Therefore, improvements in diagnostics and treatments are urgently needed. In this review …

Immune checkpoint blockers (ICB) have become pivotal therapies in the clinical
armamentarium against metastatic melanoma (MMel). Given the frequency of immune …