The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Highlights•Obesity is associated with chronic inflammation and chronic diseases.•Obesity is
associated with increased risk and progression of several cancers.•The mechanism by …

Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector
function | Journal of Experimental Medicine | Rockefeller University Press Skip to Main Content …

Although ample evidence links hepatic lipid accumulation with hepatic insulin resistance,
the mechanistic basis of this association is incompletely understood and controversial …

Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR);
however, a large variety of association and intervention studies as well as genetic …

Non-alcoholic fatty liver disease (NAFLD), including non-alcoholic fatty liver (NAFL) and non-
alcoholic steatohepatitis (NASH), represents the hepatic manifestation of obesity and …

The increasing occurrence of obesity has become a significant public health concern.
Individuals with obesity have higher prevalence of heart disease, stroke, osteoarthritis …

Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …

Gut intraepithelial lymphocytes (IELs) are thought to calibrate glucagon-like peptide 1 (GLP-
1) bioavailability, thereby regulating systemic glucose and lipid metabolism. Here, we show …

Obesity is associated with chronic, low-grade inflammation, which can disrupt homeostasis
within tissue microenvironments. Given the correlation between obesity and relative risk of …