High-fat diet (HFD) has been applied to a variety of inbred mouse strains to induce obesity
and obesity related metabolic complications. In this study, we determined HFD induced …

Brown fat generates heat through uncoupled respiration, protecting against hypothermia
and obesity. Adult humans have brown fat, but the amounts and activities are substantially …

Obesity is associated with increased incidence and severity of triple-negative breast cancer
(TNBC); however, mechanisms underlying this relationship are incompletely understood …

The etiology of non-alcoholic fatty liver disease (NAFLD), the most common form of chronic
liver disease, is poorly understood. To understand the causal mechanisms underlying …

The incidence of insulin resistance and type 2 diabetes (T2D) is increasing at alarming
rates. In the quest to understand the underlying causes of and to identify novel therapeutic …

Obesity is caused by an imbalance between food intake and energy expenditure (EE). Here
we identify a conserved pathway that links signalling through peripheral Y1 receptors (Y1R) …

Objectives Ambient temperature impinges on energy metabolism in a body size dependent
manner. This has implications for the housing temperature at which mice are best compared …

Diet is a critical element determining human health and diseases, and unbalanced food
habits are major risk factors for the development of obesity and related metabolic disorders …

The gut microbiota is involved in many aspects of host physiology but its role in body weight
and glucose metabolism remains unclear. Here we studied the compositional changes of …

Background Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic tumor with
a dismal prognosis for most patients. Fibrosis and inflammation are hallmarks of tumor …