Obesity promotes prolonged ovalbumin-induced airway inflammation modulating T helper type 1 (Th1), Th2 and Th17 immune responses in BALB/c mice
FMC Silva, EE Oliveira, ACC Gouveia… - Clinical & …, 2017 - academic.oup.com
Clinical and epidemiological studies indicate that obesity affects the development and
phenotype of asthma by inducing inflammatory mechanisms in addition to eosinophilic …
phenotype of asthma by inducing inflammatory mechanisms in addition to eosinophilic …
The RabGAP TBC1D1 plays a central role in exercise-regulated glucose metabolism in skeletal muscle
J Stöckli, CC Meoli, NJ Hoffman, DJ Fazakerley… - Diabetes, 2015 - Am Diabetes Assoc
Insulin and exercise stimulate glucose uptake into skeletal muscle via different pathways.
Both stimuli converge on the translocation of the glucose transporter GLUT4 from …
Both stimuli converge on the translocation of the glucose transporter GLUT4 from …
The effect of a sustained high-fat diet on the metabolism of white and brown adipose tissue and its impact on insulin resistance: A selected time point cross-sectional …
BR Maharjan, SV McLennan, C Yee, SM Twigg… - International Journal of …, 2021 - mdpi.com
(1) Background: studies on the long-term dynamic changes in fat depot metabolism in
response to a high-fat diet (HFD) on hepatic lipid deposition and insulin resistance are …
response to a high-fat diet (HFD) on hepatic lipid deposition and insulin resistance are …
Obesity and CD8 T cell metabolism: implications for anti‐tumor immunity and cancer immunotherapy outcomes
WJ Turbitt, C Buchta Rosean, KS Weber… - Immunological …, 2020 - Wiley Online Library
Obesity is an established risk factor for many cancers and has recently been found to alter
the efficacy of T cell–based immunotherapies. Currently, however, the effects of obesity on …
the efficacy of T cell–based immunotherapies. Currently, however, the effects of obesity on …
Genetic background and sex control the outcome of high-fat diet feeding in mice
AM Bachmann, JD Morel, G El Alam… - IScience, 2022 - cell.com
The sharp increase in obesity prevalence worldwide is mainly attributable to changes in
physical activity and eating behavior but the metabolic and clinical impacts of these …
physical activity and eating behavior but the metabolic and clinical impacts of these …
The effects of diet composition and chronic obesity on muscle growth and function
LGO de Sousa, AG Marshall… - Journal of Applied …, 2021 - journals.physiology.org
Diet-induced obesity (DIO) is associated with glucose intolerance, insulin resistance (IR),
and an increase in intramyocellular lipids (IMCL), which may lead to disturbances in glucose …
and an increase in intramyocellular lipids (IMCL), which may lead to disturbances in glucose …
Mouse strain-dependent variation in metabolic associated fatty liver disease (MAFLD): a comprehensive resource tool for pre-clinical studies
H Karimkhanloo, SN Keenan, J Bayliss, W De Nardo… - Scientific reports, 2023 - nature.com
Abstract Non-alcoholic steatohepatitis (NASH), characterized as the joint presence of
steatosis, hepatocellular ballooning and lobular inflammation, and liver fibrosis are strong …
steatosis, hepatocellular ballooning and lobular inflammation, and liver fibrosis are strong …
Heparanase accelerates obesity-associated breast cancer progression
E Hermano, R Goldberg, AM Rubinstein… - Cancer Research, 2019 - AACR
Obese women have higher risk of bearing breast tumors that are highly aggressive and
resistant to therapies. Tumor-promoting effects of obesity occur locally via adipose …
resistant to therapies. Tumor-promoting effects of obesity occur locally via adipose …
Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials
P Møller, DV Christophersen… - Critical reviews in …, 2016 - Taylor & Francis
Exposure to particulate matter (PM) from traffic vehicles is hazardous to the vascular system,
leading to clinical manifestations and mortality due to ischemic heart disease. By analogy …
leading to clinical manifestations and mortality due to ischemic heart disease. By analogy …
[HTML][HTML] Epigenetic control of variation and stochasticity in metabolic disease
I Panzeri, JA Pospisilik - Molecular metabolism, 2018 - Elsevier
Background The alarming rise of obesity and its associated comorbidities represents a
medical burden and a major global health and economic issue. Understanding etiological …
medical burden and a major global health and economic issue. Understanding etiological …