Regulated cell death (RCD) is either immunologically silent or immunogenic. RCD in
parenchymal cells may lead to the release of damage-associated molecular patterns that …

Matrix metalloproteinases (MMPs) constitute a family of more than 20 endopeptidases.
Identification of specific matrix and non-matrix components as MMP substrates showed that …

Loss of kidney function in renal ischemia/reperfusion injury is due to programmed cell death,
but the contribution of necroptosis, a newly discovered form of programmed necrosis, has …

Oxidative stress is a widely recognized cause of cell death associated with
neurodegeneration, inflammation, and aging. Tyrosine nitration in these conditions has …

Recent evidence shows that many molecules of the TNF family serve as counter-receptors,
inducing costimulation through reverse signals in addition to delivering signals through their …

Intravenous administration of bacteria leads to their accumulation in tumors and to sporadic
tumor regression. We therefore explored the hypothesis that Salmonella typhimurium …

Secretory lysosomes are specialized organelles that combine catabolic functions of
conventional lysosomes with an inducible secretory potential. They are present in various …

Direct cell-cell spread of Human Immunodeficiency Virus type-1 (HIV-1) at the virological
synapse (VS) is an efficient mode of dissemination between CD4+ T cells but the …

Fas ligand (FasL, CD95L, APO-1L, CD178, TNFSF6, APT1LG1) is the key death factor of
receptor-triggered programmed cell death in immune cells. FasL/Fas-dependent apoptosis …

Cisplatin, a standard chemotherapeutic agent for many tumors, has an unfortunately
common toxicity where almost a third of patients develop renal dysfunction after a single …