Antibiotic resistance: The challenges and some emerging strategies for tackling a global menace

D Chinemerem Nwobodo, MC Ugwu… - Journal of clinical …, 2022 - Wiley Online Library
Background Antibiotic resistance is currently the most serious global threat to the effective
treatment of bacterial infections. Antibiotic resistance has been established to adversely …

The pathogenesis and potential therapeutic targets in sepsis

W Zhang, H Jiang, G Wu, P Huang, H Wang, H An… - MedComm, 2023 - Wiley Online Library
Sepsis is defined as “a life‐threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection.” At present, sepsis continues to …

Recent advances in electrochemiluminescence biosensors for MicroRNA detection

X Meng, X Pang, J Yang, X Zhang, H Dong - Small, 2024 - Wiley Online Library
Electrochemiluminescence (ECL) as an analytical technology with a perfect combination of
electrochemistry and spectroscopy has received considerable attention in bioanalysis due to …

[HTML][HTML] Suppressing the substance P-NK1R signalling protects mice against sepsis-associated acute inflammatory injury and ferroptosis in the liver and lungs

Z Zhu, S Chambers, M Bhatia - Antioxidants, 2024 - mdpi.com
Substance P (SP), encoded by the TAC1/Tac1 gene, acts as a significant mediator in
dysregulated systemic inflammatory response and associated organ injury in sepsis by …

[HTML][HTML] Antibiotic resistance: challenges and strategies in combating infections

J Chavada, KN Muneshwar, Y Ghulaxe, M Wani… - Cureus, 2023 - ncbi.nlm.nih.gov
From a broader perspective, antibiotic or antimicrobial resistance is still evolving and
spreading internationally. Infectious diseases have become more complex and often …

Physiologic disruption and metabolic reprogramming in infection and sepsis

K Willmann, LF Moita - Cell Metabolism, 2024 - cell.com
Effective responses against severe systemic infection require coordination between two
complementary defense strategies that minimize the negative impact of infection on the host …

Application and value of hydrogen sulfide modulated autophagy in sepsis

Y Sun, C Liu - International Immunopharmacology, 2023 - Elsevier
Sepsis is is an abnormal host immune response caused by infection. Antibiotics, anti-viral
drugs, and vasoactive drugs have always been used in the traditional treatment of sepsis …

Causal relationships between lung cancer and sepsis: a genetic correlation and multivariate mendelian randomization analysis

J Zhou, Y Zhang, T Yang, K Zhang, A Li, M Li… - Frontiers in …, 2024 - frontiersin.org
Background Former research has emphasized a correlation between lung cancer (LC) and
sepsis, but the causative link remains unclear. Method This study used univariate Mendelian …

[HTML][HTML] Hydrogen sulfide: a gaseous mediator and its key role in programmed cell death, oxidative stress, inflammation and pulmonary disease

Z Zhu, X Lian, M Bhatia - Antioxidants, 2022 - mdpi.com
Hydrogen sulfide (H2S) has been acknowledged as a novel gaseous mediator. The
metabolism of H2S in mammals is tightly controlled and is mainly achieved by many …

Contractile Function of the Capsule of the Bovine Mesenteric Lymph Nodes at the Early Stage of Inflammation

GI Lobov - Journal of Evolutionary Biochemistry and Physiology, 2022 - Springer
Inflammation is detected not only in infections or injuries, but also in many other pathological
processes associated with tissue dysfunction, such as type 2 diabetes mellitus …