The Diabetes Control and Complications Trial (DCCT, 1983–1993) showed that intensive
therapy (mean HbA1c 7.2%) compared with conventional therapy (mean HbA1c 9.0%) …

Macrovascular complications such as atherosclerosis, myocardial infarction and stroke, and
microvascular complications such as nephropathy, retinopathy, and neuropathy are the …

High-throughput proteomic profiling using antibody or aptamer-based affinity reagents is
used increasingly in human studies. However, direct analyses to address the relative …

Epigenetic changes may fill a critical gap in our understanding of kidney disease
development, as they not only reflect metabolic changes but are also preserved and …

A long-term complication of obesity is the development of type 2 diabetes (T2D). Patients
with T2D have been described as having epigenetic modifications. Epigenetics is the post …

Diabetic nephropathy (DN) is a polygenic disorder with few risk variants showing robust
replication in large-scale genome-wide association studies. To understand the role of DNA …

Recent epigenome-wide studies suggest an association between blood DNA methylation
and kidney function. However, the pathological importance remains unclear. Here, we show …

ABSTRACT DNA methylation (DNAm) is one of the most studied epigenetic modifications.
DNAm has emerged as a key biological mechanism and biomarkers to test associations …

Epigenetic memory, which refers to the ability of cells to retain and transmit epigenetic marks
to their daughter cells, maintains unique gene expression patterns. Establishing …

Type 1 diabetes is a chronic autoimmune disease in which the destruction of pancreatic β
cells leads to hyperglycemia. The prevention of hyperglycemia is very important to avoid or …