The orexin-A/hypocretin-1 and orexin-B/hypocretin-2 are neuropeptides synthesized by a
cluster of neurons in the lateral hypothalamus and perifornical area. Orexin neurons receive …

Body weight is determined by a balance between food intake and energy expenditure.
Multiple neural circuits in the brain have evolved to process information about food, food …

Orexins, or hypocretins, are excitatory neuropeptides involved in the regulation of feeding
behavior and the sleep and wakefulness states. Since their discovery, several lines of …

The hypothalamic neuropeptides orexin A and B (hypocretin 1 and 2) are important
homeostatic mediators of central control of energy metabolism and maintenance of …

The adipocyte-derived hormone leptin modulates neural systems appropriately for the status
of body energy stores. Leptin inhibits lateral hypothalamic area (LHA) orexin (OX; also …

The lateral hypothalamus is critical for the control of ingestive behavior and spontaneous
physical activity (SPA), as lesion or stimulation of this region alters these behaviors …

Since hypothalamic obesity (HyOb) was first described over 120 years ago by Joseph
Babinski and Alfred Fröhlich, advances in molecular genetic laboratory techniques have …

Obesity and metabolic diseases are linked to chronic stress and low socioeconomic status.
The mechanistic link between stress and obesity has not been clarified, partly due to the …

Exercise represents the most important integrative therapy in metabolic, immunologic and
chronic diseases; it represents a valid strategy in the non-pharmacological intervention of …

Results: Activation of orexin resulted in increases in SPA in male and female mice, and was
accompanied by increases in energy expenditure without changes in overall chow intake …