TP53 co-mutations in advanced EGFR-mutated non–small cell lung cancer: Prognosis and therapeutic strategy for cancer therapy

S Liu, J Yu, H Zhang, J Liu - Frontiers in oncology, 2022 - frontiersin.org
Lung cancer is the leading cause of cancer-related deaths worldwide. As the most prevalent
molecular mutation subtypes in non-small cell lung cancer (NSCLC), EGFR-TKIs are …

Polymeric micellar paclitaxel (Pm-Pac) prolonged overall survival for NSCLC patients without pleural metastasis

J Lu, A Gu, W Wang, A Huang, B Han… - International Journal of …, 2022 - Elsevier
Nanoparticle polymeric micellar paclitaxel (Pm-Pac) has been demonstrated to have a
safety profile and efficacy in advanced non-small cell lung cancer (NSCLC) patients …

Blood-based tumour mutation index act as prognostic predictor for immunotherapy and chemotherapy in non-small cell lung cancer patients

J Lu, J Wu, Y Lou, Q Shi, J Xu, L Zhang, W Nie… - Biomarker …, 2022 - Springer
Abstract Background Circulating tumour DNA (ctDNA)-based sequencing might provide a
simple test for the stratified model of non-small cell lung cancer (NSCLC). Here, we aimed to …

Paclitaxel has a reduced toxicity profile in healthy rats after polymeric micellar nanoparticle delivery

J Lu, Y Lou, Y Zhang, R Zhong, W Zhang… - International Journal …, 2023 - Taylor & Francis
Background Nanocarrier platforms have been indicated to have great potential in clinical
practice to treat non-small cell lung cancer (NSCLC). Our previous Phase III clinical study …

A novel immunogenomic classification for prognosis in non-small cell lung cancer

S Tang, L Xu, Z Wu, Q Wen, H Li, N Li - Journal of Cancer Research and …, 2023 - Springer
Objective To facilitate immunotherapy and prognostic assessment of non-small cell lung
cancer (NSCLC), we established a novel immunogenomic classification to provide valid …

KEAP1 and TP53 (Co) mutation in lung adenocarcinoma: another bullet for immunotherapy?

G Pelosi - Journal of Thoracic Oncology, 2021 - jto.org
That impairment of immune response may actually play an active role in the development of
NSCLC, it is well anticipated by the beneficial effects of tumor lymphocytic infiltration on the …

[HTML][HTML] Dynamic alterations of ctDNA associate with the therapeutic outcome in the advanced non‐small cell lung cancer patients who received sintilimab plus …

T Chu, J Yuan, J Lu, W Nie, R Zhong… - Clinical and …, 2023 - ncbi.nlm.nih.gov
Dear Editor, In our previous study (NCT03628521), the efficacy and safety of sintilimab plus
anlotinib regime have been evaluated upon the patients with advanced non-small cell lung …

Multi-omics signatures identification for LUAD prognosis prediction model based on the integrative analysis of immune and hypoxia signals

Y Lou, Q Shi, Y Zhang, Y Qi, W Zhang… - Frontiers in Cell and …, 2022 - frontiersin.org
Lung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer with
heterogeneous outcomes and diverse therapeutic responses. However, the understanding …

Screening anlotinib responders via blood‐based proteomics in non‐small cell lung cancer

J Lu, W Zhang, K Yu, L Zhang, Y Lou, P Gu… - The FASEB …, 2022 - Wiley Online Library
Anlotinib has been demonstrated to be effective in advanced non‐small cell lung cancer
(NSCLC) patients. The response stratification of anlotinib remains unclear. In this study …

PEG2000-PLA-based nanoscale polymeric micelles reduce paclitaxel-related toxicity in beagle dogs

J Lu, B Han, B Zhang, B Zou, M Hu, H Liu… - … Clinics and Research, 2023 - journals.lww.com
Nanoplatform-based drug delivery plays an important role in clinical practice. Polymeric
micellar (Pm) nanocarriers have been demonstrated to reduce the toxicity of paclitaxel in …