Tau protein interaction partners and their roles in Alzheimer's disease and other tauopathies

J Sinsky, K Pichlerova, J Hanes - International journal of molecular …, 2021 - mdpi.com
Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

How does adenosine control neuronal dysfunction and neurodegeneration?

RA Cunha - Journal of neurochemistry, 2016 - Wiley Online Library
The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …

Flavonoids: antioxidants or signalling molecules?

RJ Williams, JPE Spencer, C Rice-Evans - Free radical biology and …, 2004 - Elsevier
Many studies are accumulating that report the neuroprotective, cardioprotective, and
chemopreventive actions of dietary flavonoids. While there has been a major focus on the …

Potential mechanisms of action of lithium in bipolar disorder: Current understanding

GS Malhi, M Tanious, P Das, CM Coulston, M Berk - CNS drugs, 2013 - Springer
Lithium has been used for over half a century for the treatment of bipolar disorder as the
archetypal mood stabilizer, and has a wealth of empirical evidence supporting its efficacy in …

Microglial activation and its implications in the brain diseases

S Thameem Dheen, C Kaur… - Current medicinal …, 2007 - ingentaconnect.com
An inflammatory process in the central nervous system (CNS) is believed to play an
important role in the pathway leading to neuronal cell death in a number of …

[HTML][HTML] Flavonoid-based therapies in the early management of neurodegenerative diseases

I Solanki, P Parihar, ML Mansuri, MS Parihar - Advances in nutrition, 2015 - Elsevier
During the past several years, there has been enormous progress in the understanding of
the causative factors that initiate neuronal damage in various neurodegenerative diseases …

Programmed cell death pathways in hearing loss: A review of apoptosis, autophagy and programmed necrosis

J Wu, J Ye, W Kong, S Zhang, Y Zheng - Cell proliferation, 2020 - Wiley Online Library
Programmed cell death (PCD)—apoptosis, autophagy and programmed necrosis—is any
pathological form of cell death mediated by intracellular processes. Ototoxic drugs, ageing …

Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activation

HJ Huttunen, J Kuja-Panula, G Sorci… - Journal of Biological …, 2000 - ASBMB
Amphoterin is a protein enhancing process extension and migration in embryonic neurons
and in tumor cells through binding to receptor for advanced glycation end products (RAGE) …

Natural polyphenols against neurodegenerative disorders: potentials and pitfalls

A Ebrahimi, H Schluesener - Ageing research reviews, 2012 - Elsevier
Within the last years, a rapidly growing number of polyphenolic compounds with
neuroprotective effects have been described. Many efforts have been made to explore the …

Flavonoids: modulators of brain function?

JPE Spencer - British journal of nutrition, 2008 - cambridge.org
Emerging evidence suggests that dietary phytochemicals, in particular flavonoids, may exert
beneficial effects on the central nervous system by protecting neurons against stress …