Evaluation of antibiotic resistance mechanisms in gram-negative bacteria

A Gauba, KM Rahman - Antibiotics, 2023 - mdpi.com
Multidrug-resistant Gram-negative bacterial infections are exponentially increasing, posing
one of the most urgent global healthcare and economic threats. Due to the lack of new …

[HTML][HTML] AcrAB− TolC, a major efflux pump in Gram negative bacteria: toward understanding its operation mechanism

S Jang - BMB reports, 2023 - ncbi.nlm.nih.gov
Antibiotic resistance (AR) is a silent pandemic that kills millions worldwide. Although the
development of new therapeutic agents against antibiotic resistance is in urgent demand …

Inhibition of multidrug efflux pumps belonging to the major facilitator superfamily in bacterial pathogens

MF Varela, J Stephen, D Bharti, M Lekshmi, S Kumar - Biomedicines, 2023 - mdpi.com
Bacterial pathogens resistant to multiple structurally distinct antimicrobial agents are
causative agents of infectious disease, and they thus constitute a serious concern for public …

The balance between antibiotic resistance and fitness/virulence in Pseudomonas aeruginosa: an update on basic knowledge and fundamental research

E Jordana-Lluch, IM Barceló… - Frontiers in …, 2023 - frontiersin.org
The interplay between antibiotic resistance and bacterial fitness/virulence has attracted the
interest of researchers for decades because of its therapeutic implications, since it is …

The Art of War with Pseudomonas aeruginosa: Targeting Mex Efflux Pumps Directly to Strategically Enhance Antipseudomonal Drug Efficacy

A Avakh, GD Grant, MJ Cheesman, T Kalkundri, S Hall - Antibiotics, 2023 - mdpi.com
Pseudomonas aeruginosa (P. aeruginosa) poses a grave clinical challenge due to its
multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections …

Mechanisms of Antibiotic and Biocide Resistance That Contribute to Pseudomonas aeruginosa Persistence in the Hospital Environment

C Verdial, I Serrano, L Tavares, S Gil, M Oliveira - Biomedicines, 2023 - mdpi.com
Pseudomonas aeruginosa is an opportunistic bacterial pathogen responsible for multiple
hospital-and community-acquired infections, both in human and veterinary medicine. P …

Nonlethal Molecular Nanomachines Potentiate Antibiotic Activity Against Gram-Negative Bacteria by Increasing Cell Permeability and Attenuating Efflux

AL Santos, D Liu, A van Venrooy, JL Beckham… - ACS …, 2024 - ACS Publications
Antibiotic resistance is a pressing public health threat. Despite rising resistance, antibiotic
development, especially for Gram-negative bacteria, has stagnated. As the traditional …

Resistance in Pseudomonas aeruginosa: A Narrative Review of Antibiogram Interpretation and Emerging Treatments

F Giovagnorio, A De Vito, G Madeddu, SG Parisi… - Antibiotics, 2023 - mdpi.com
Pseudomonas aeruginosa is a ubiquitous Gram-negative bacterium renowned for its
resilience and adaptability across diverse environments, including clinical settings, where it …

Emerging strategies to target virulence in Pseudomonas aeruginosa respiratory infections

TM Hibbert, M Whiteley, SA Renshaw… - Critical reviews in …, 2023 - Taylor & Francis
Pseudomonas aeruginosa is an opportunistic pathogen that is responsible for infections in
people living with chronic respiratory conditions, such as cystic fibrosis (CF) and non-CF …

A molecular overview of the polymyxin-LPS interaction in the context of its mode of action and resistance development

I Padhy, SK Dwibedy, SS Mohapatra - Microbiological Research, 2024 - Elsevier
With the rising incidences of antimicrobial resistance (AMR) and the diminishing options of
novel antimicrobial agents, it is paramount to decipher the molecular mechanisms of action …