Peptide-based strategies have received an enormous amount of attention because of their
specificity and applicability. Their specificity and tumor-targeting ability are applied to …

Developing novel therapeutics often follows three steps: target identification, design of
strategies to suppress target activity and drug development to implement the strategies. In …

Every cell biological textbook teaches us that the main role of the plasma membrane is to
separate cells from their neighborhood to allow for a controlled composition of the …

The therapeutic potential of short interfering RNA (siRNA) to treat many diseases that are
incurable with traditional preparations is limited by the extensive metabolism of serum …

Cell‐penetrating peptides (CPPs) encompass a class of peptides that possess the
remarkable ability to cross cell membranes and deliver various types of cargoes, including …

Chemotherapy is the main treatment for most early-stage cancers; nevertheless, its efficacy
is usually limited by drug resistance, toxicity, and tumor heterogeneity. Cell-penetrating …

Abstract Cell‐penetrating peptides (CPPs), first identified in HIV a few decades ago,
deserved great attention in the last two decades; especially to support the penetration of …

Abstract Heat shock protein 90 (Hsp90) and cell division cycle 37 (Cdc37) work together as
a molecular chaperone complex to regulate the activity of a multitude of client protein …

The efficiency of the intracellular transport of medication and target specificity is frequently
hampered by biological obstacles. The potential for therapeutic use of peptide fragments …

Chronic myeloid leukemia (CML) is recognized as a classic clonal myeloproliferative
disorder. Given the limited treatment options for CML patients in the accelerated phase (AP) …