Redox regulation of the immune response

G Morris, M Gevezova, V Sarafian… - Cellular & Molecular …, 2022 - nature.com
The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

YQ He, CC Zhou, LY Yu, L Wang, J Deng… - Pharmacological …, 2021 - Elsevier
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome
(ARDS) as common life-threatening lung diseases with high mortality rates are mostly …

SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis

L Feng, K Zhao, L Sun, X Yin, J Zhang, C Liu… - Journal of Translational …, 2021 - Springer
Background Solute carrier family 7 member 11 (SLC7A11) is a component of
cysteine/glutamate transporter, which plays a key role in tumor growth; however, its …

Can activation of NRF2 be a strategy against COVID-19?

A Cuadrado, M Pajares, C Benito… - Trends in …, 2020 - cell.com
Acute respiratory distress syndrome (ARDS) caused by SARS-CoV-2 is largely the result of
a dysregulated host response, followed by damage to alveolar cells and lung fibrosis …

[HTML][HTML] Can early and high intravenous dose of vitamin C prevent and treat coronavirus disease 2019 (COVID-19)?

RZ Cheng - Medicine in drug discovery, 2020 - ncbi.nlm.nih.gov
The COVID-19 (SARS-2-Cov) pandemic, first reported in Wuhan, China, is now spreading to
many continents and countries, causing a severe public health burden. Currently, there is no …

[HTML][HTML] Pathogenesis of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke

M Hikichi, K Mizumura, S Maruoka… - Journal of thoracic …, 2019 - ncbi.nlm.nih.gov
Chronic obstructive pulmonary disease (COPD) is a common respiratory disease that is
characterized by functional and structural alterations primarily caused by long-term …

Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome

A Boretti, BK Banik - PharmaNutrition, 2020 - Elsevier
The recent outbreak of Covid19 has required urgent treatments for numerous patients. No
suitable vaccines or antivirals are available for Covid19. The efficiency against Covid19 of …

Understanding cellular redox homeostasis: A challenge for precision medicine

V Tretter, B Hochreiter, ML Zach, K Krenn… - International journal of …, 2021 - mdpi.com
Living organisms use a large repertoire of anabolic and catabolic reactions to maintain their
physiological body functions, many of which include oxidation and reduction of substrates …

Melatonin attenuates LPS-induced pyroptosis in acute lung injury by inhibiting NLRP3-GSDMD pathway via activating Nrf2/HO-1 signaling axis

JY Kang, MM Xu, Y Sun, ZX Ding, YY Wei… - International …, 2022 - Elsevier
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is featured by intensive
inflammatory responses and oxidative stress, which lead to cytokine storms and pyroptosis …

Astragaloside IV regulates the ferroptosis signaling pathway via the Nrf2/SLC7A11/GPX4 axis to inhibit PM2. 5-mediated lung injury in mice

X Wang, Y Wang, D Huang, S Shi, C Pei, Y Wu… - International …, 2022 - Elsevier
Objective Exposure to PM2. 5 will increase the risk of respiratory disease and increase the
burden of social health care. Astragaloside Ⅳ (Ast-IV) is one of the main biologically active …