Addiction is associated with neuroplasticity in the corticostriatal brain circuitry that is
important for guiding adaptive behaviour. The hierarchy of corticostriatal information …

A growing body of evidence indicates that repeated exposure to cocaine leads to profound
changes in glutamate transmission in limbic nuclei, particularly the nucleus accumbens. This …

MicroRNAs play key regulatory roles in cellular processes including neurogenesis, synapse
development and plasticity in the brain. Psychostimulants induces strong neuroadaptive …

In animal models of drug addiction, cocaine exposure has been shown to increase levels of
calcium-permeable AMPA receptors (CP-AMPARs) in two brain regions that are critical for …

Learning to inhibit drug seeking can be an important strategy for inhibiting relapse, and this
can be modeled by extinguishing drug seeking in response to a drug-paired context. Rats …

Activation of medium spiny neurons (MSNs) of the nucleus accumbens is critical for goal-
directed behaviors including cocaine seeking. Studies in cocaine-experienced rodents have …

Molecular adaptations underlying drug seeking and relapse remain largely unknown.
Studies highlight post-transcriptional modifications mediated by microRNAs (miRNAs) in …

Environmental stimuli are powerful mediators of craving and relapse in substance‐abuse
disorders. This review examined how animal models have been used to investigate the …

Drug addiction remains a key biomedical challenge facing current neuroscience research. In
addition to neural mechanisms, the focus of the vast majority of studies to date, astrocytes …

Accumulating evidence suggests that metabotropic glutamate receptors (mGluRs) are
involved in both cocaine reinforcement and the reinstatement of cocaine-seeking behavior …