Bioengineering approaches for nerve graft revascularization: Current concepts and future directions

C Pereira, SV Lazar, A Wang - WIREs Mechanisms of Disease, 2023 - Wiley Online Library
Peripheral nerve injury (PNI) is the most common neurological injury in civilian and military
injuries, with over 360,000 PNI procedures performed in the US yearly. Segmental loss of …

[HTML][HTML] 人脂肪干细胞外泌体对糖尿病周围神经病变的作用及其机制

曹涛, 郝彤, 肖丹, 张伟锋, 计鹏… - 中华烧伤与创面 …, 2024 - zhsszz.xml-journal.net
目的探讨糖尿病周围神经病变(DPN) 中神经鞘胚素蛋白表达的变化及人脂肪干细胞(ADSC)
外泌体对神经鞘胚素蛋白表达变化的调节作用. 方法该研究为前瞻性观察性临床研究联合实验 …

[HTML][HTML] Improving Schwann Cell Differentiation from Human Adipose Stem Cells with Metabolic Glycoengineering

J Du, Z Wang, X Liu, C Hu, KJ Yarema, X Jia - Cells, 2023 - mdpi.com
Schwann cells (SCs) are myelinating cells that promote peripheral nerve regeneration.
When nerve lesions form, SCs are destroyed, ultimately hindering nerve repair. The difficulty …

[HTML][HTML] Harnessing three-dimensional porous chitosan microsphere embedded with adipose-derived stem cells to promote nerve regeneration

Y Zhu, D Yi, J Wang, Y Zhang, M Li, J Ma, Y Ji… - Stem Cell Research & …, 2024 - Springer
Background Nerve guide conduits are a promising strategy for reconstructing peripheral
nerve defects. Improving the survival rate of seed cells in nerve conduits is still a challenge …

Therapeutic Potential and Challenges of Mesenchymal Stem Cell-Derived Exosomes for Peripheral Nerve Regeneration: A Systematic Review

C Dogny, D André-Lévigne, DF Kalbermatten… - International Journal of …, 2024 - mdpi.com
Gap injuries to the peripheral nervous system result in pain and loss of function, without any
particularly effective therapeutic options. Within this context, mesenchymal stem cell (MSC) …

Injectable Prevascularized Mature Adipose Tissues (iPAT) to Achieve Long‐Term Survival in Soft Tissue Regeneration

F Louis, Y Sowa, S Irie, Y Higuchi… - Advanced …, 2022 - Wiley Online Library
Soft tissue regeneration remains a challenge in reconstructive surgery. So far, both
autologous fat implantations and artificial implants methods used in clinical applications …

[HTML][HTML] Pericyte‑derived extracellular vesicles‑mimetic nanovesicles improves peripheral nerve regeneration in mouse models of sciatic nerve transection

GN Yin, TY Shin, J Ock, MJ Choi… - International …, 2022 - spandidos-publications.com
Pericyte‑derived extracellular vesicle‑mimetic nanovesicles (PC‑NVs) play an important role
in the improvement of erectile function after cavernous nerve injury. However, the impact of …

Combining chitin biological conduits with injectable adipose tissue-derived decellularised matrix hydrogels loaded with adipose-derived mesenchymal stem cells for …

Y Li, Z Chen, J Zhou, Y Guan, J Xing, Z Niu… - Colloids and Surfaces A …, 2023 - Elsevier
Mesenchymal stem cells (MSCs) have shown potential for the repair of defective tissues and
peripheral nerve injuries. However, local treatment alone may lead to cell loss, low viability …

Role of the store-operated Ca2+ channel in ATP-induced Ca2+ signalling in mesenchymal stem cells and regulation of cell functions

L Wang, S Roger, XB Yang… - Frontiers in Bioscience …, 2021 - eprints.whiterose.ac.uk
It is well-known that extracellular ATP acts as an autocrine/paracrine signal to regulate cell
functions by inducing intracellular Ca2+ signalling through its cognate receptors, namely …

Application of Adipose Stem Cells in 3D Nerve Guidance Conduit Prevents Muscle Atrophy and Improves Distal Muscle Compliance in a Peripheral Nerve …

C Trâmbițaș, BA Cordoș, DC Dorobanțu, C Vintilă… - Bioengineering, 2024 - mdpi.com
Background: Peripheral nerve injuries (PNIs) represent a significant clinical problem, and
standard approaches to nerve repair have limitations. Recent breakthroughs in 3D printing …