The early-life social environment can induce stable changes that influence
neurodevelopment and mental health. Research focused on early-life adversity revealed …

DNA methylation (DNAm)–an epigenetic process that regulates gene expression–may
represent a mechanism for the biological embedding of early traumatic experiences …

Background According to several studies, the onset of the Borderline Personality Disorder
(BPD) depends on the combination between genetic and environmental factors (GxE), in …

Downregulation of brain-derived neurotrophic factor (BDNF) gene expression with
corresponding increased methylation at specific promoters has been associated with …

HPA axis genes implicated in glucocorticoid regulation play an important role in regulating
the physiological impact of social and environmental stress, and have become a focal point …

The last two decades have seen a strong rise in empirical research in the mechanisms of
emotion dysregulation in borderline personality disorder. Major findings comprise structural …

Stress, particularly when experienced early in life, can have profound implications for mental
health. Previous research covering various tissues such as the brain, suggests that the …

The hypothalamus-pituitary-adrenal axis (HPA) is essential in the regulation of stress
responses. Increased methylation of the promoter region of the glucocorticoid receptor gene …

The glucocorticoid receptor gene (NR3C1) is a critical component of the stress response
system. Cytosine methylation of NR3C1 has been repeatedly associated with trauma and …

Borderline personality disorder (BPD) is a severe mental disorder with a multifactorial
etiology. The development and maintenance of BPD is sustained by diverse neurobiological …