Knowledge of the protein networks interacting with the amyloid precursor protein (APP) in
vivo can shed light on the physiological function of APP. To date, most proteins interacting …

Alzheimer's disease (AD) is a neurodegenerative disorder that represents the most common
type of dementia in the elderly. One of the hallmarks of this disease is a progressive …

The 99 amino acid C-terminal fragment of Amyloid Precursor Protein APP-C99 (C99) is
cleaved by γ-secretase to form Aβ peptide, which plays a critical role in the etiology of …

J. Neurochem.(2010) 115, 1299–1308. Abstract In recent decades, the study of the amyloid
precursor protein (APP) and of its proteolytic products carboxy terminal fragment (CTF), APP …

The amyloid precursor protein (APP) and the presenilins 1 and 2 are genetically linked to
the development of familial Alzheimer disease. APP is a single-pass transmembrane protein …

The functions of the Alzheimer's β-amyloid precursor protein (APP) and of its complex with
the adaptor protein Fe65 are still unknown. We have demonstrated that Fe65 is also a …

The amyloid precursor protein (APP) is an ubiquitous receptor-like molecule involved in the
pathogenesis of Alzheimer's disease that generates β-amyloid peptides and causes plaque …

The pathogenic model of Alzheimer's disease (AD) posits that aggregates of amyloid β, a
product of amyloid precursor protein (APP) processing, cause dementia. However …

The amyloid precursor protein (APP) is proteolytically processed to release a C-terminal
domain that signals to the nucleus to regulate transcription of responsive genes. The APP C …

The β-amyloid peptide (Aβ) present in the senile plaques of Alzheimer's disease derives
from the cleavage of a membrane protein, named APP, driven by two enzymes, known as β …