The multigenic family of mammalian Fe65s encodes three highly similar proteins with the
same modular organisation: a WW domain and two phosphotyrosine-binding domains. The …

The β-amyloid precursor protein APP and the microtubule-associated protein Tau play a
crucial role in the pathogenesis of Alzheimer's disease (AD). However, the possible …

The cytoplasmic tail of the β-amyloid precursor protein (APP) contains a Y 682ENPTY 687
sequence through which APP associates with phosphotyrosine binding (PTB) domain …

Since its proposal in 1994, the amyloid cascade hypothesis has prevailed as the
mainstream research subject on the molecular mechanisms leading to the Alzheimer′ s …

We have examined the global gene expression profile of small intestinal carcinoids by
microarray analysis. High expression of a number of genes was found including amyloid …

Abstract Background Niemann-Pick type C (NPC) disease is characterized by lysosomal
accumulation of cholesterol. Interestingly, NPC patients' brains also show increased levels …

Communication between distant cells can be mediated by extracellular vesicles (EVs) that
deliver proteins and RNAs to recipient cells. Little is known about how EVs are targeted to …

Signal transduction in a broad sense refers to intracellular, molecular changes triggered by
cues outside the cell in order to bring about behavioral responses such as migration …

An unstable expansion of the polyglutamine repeat within exon 1 of the protein Htt
(huntingtin) causes HD (Huntington's disease). Mounting evidence shows that accumulation …

Enabled homolog (Enah) is a mammalian ortholog of Drosophila Enabled (Ena), which is
genetically linked to the Drosophila Abl tyrosine phosphorylation signaling cascade and is …