The microbiome, cancer, and cancer therapy

BA Helmink, MAW Khan, A Hermann… - Nature medicine, 2019 - nature.com
With the advent of next-generation sequencing, we have an unprecedented ability to study
tumor and host genomes as well as those of the vast array of microorganisms that exist …

The gut–liver axis and the intersection with the microbiome

A Tripathi, J Debelius, DA Brenner, M Karin… - Nature reviews …, 2018 - nature.com
In the past decade, an exciting realization has been that diverse liver diseases—ranging
from nonalcoholic steatohepatitis, alcoholic steatohepatitis and cirrhosis to hepatocellular …

Oral–gut microbiome axis in gastrointestinal disease and cancer

SY Park, BO Hwang, M Lim, SH Ok, SK Lee, KS Chun… - Cancers, 2021 - mdpi.com
Simple Summary Microbiota dysbiosis is correlated with numerous diseases in the human
body. To date, the research on the microbiome-associated diseases been focused on an …

Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

Z Zhang, H Tang, P Chen, H Xie, Y Tao - Signal transduction and …, 2019 - nature.com
The trillions of microorganisms in the gut microbiome have attracted much attention recently
owing to their sophisticated and widespread impacts on numerous aspects of host …

The impact of mushroom polysaccharides on gut microbiota and its beneficial effects to host: A review

C Yin, GD Noratto, X Fan, Z Chen, F Yao, D Shi… - Carbohydrate …, 2020 - Elsevier
Mushroom polysaccharides are a type of bioactive macromolecular which isolated from
fruiting bodies, mycelia or fermentation broths of edible or medicinal fungus. Recently …

Current understanding of the intratumoral microbiome in various tumors

C Xue, Q Chu, Q Zheng, X Yuan, Y Su, Z Bao, J Lu… - Cell Reports …, 2023 - cell.com
It is estimated that in the future, the number of new cancer cases worldwide will exceed the
19.3 million recorded in 2020, and the number of deaths will exceed 10 million. Cancer …

Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome

Y Lee, N Kamada, JJ Moon - Advanced drug delivery reviews, 2021 - Elsevier
The gastrointestinal tract (GIT) affects not only local diseases in the GIT but also various
systemic diseases. Factors that can affect the health and disease of both GIT and the human …

Intracellular bacteria in cancer—Prospects and debates

L Schorr, M Mathies, E Elinav, J Puschhof - npj Biofilms and …, 2023 - nature.com
Recent evidence suggests that some human cancers may harbor low-biomass microbial
ecosystems, spanning bacteria, viruses, and fungi. Bacteria, the most-studied kingdom in …

Vitamin D signaling through induction of paneth cell defensins maintains gut microbiota and improves metabolic disorders and hepatic steatosis in animal models

D Su, Y Nie, A Zhu, Z Chen, P Wu, L Zhang… - Frontiers in …, 2016 - frontiersin.org
Metabolic syndrome (MetS), characterized as obesity, insulin resistance, and non-alcoholic
fatty liver diseases (NAFLD), is associated with vitamin D insufficiency/deficiency in …

The gut microbiome and efficacy of cancer immunotherapy

G Roviello, LF Iannone, M Bersanelli, E Mini… - Pharmacology & …, 2022 - Elsevier
Cancer treatment has been deeply changed by immunotherapy, achieving unprecedented
improvement in overall and progression-free survival in several advanced and metastatic …