Molecular glues and induced proximity: An evolution of tools and discovery
SA Robinson, SM Banik - Cell Chemical Biology, 2024 - cell.com
Small molecule molecular glues can nucleate protein complexes and rewire interactomes.
Molecular glues are widely used as probes for understanding functional proximity at a …
Molecular glues are widely used as probes for understanding functional proximity at a …
Discovery of SOCS7 as a versatile E3 ligase for protein-based degraders
A Cornebois, M Sorbara, M Cristol, E Vigne… - Iscience, 2024 - cell.com
Targeted protein degradation (TPD) strategy harnesses the ubiquitin-proteasome system
(UPS) to degrade a protein of interest (POI) by bringing it into proximity with an E3 ubiquitin …
(UPS) to degrade a protein of interest (POI) by bringing it into proximity with an E3 ubiquitin …
Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases
A Shemorry, W den Besten, MM Mulvihill… - bioRxiv, 2024 - biorxiv.org
Proximity-inducing compounds that modulate target protein homeostasis are an emerging
therapeutic strategy [1]. While the inherent complexity of these bifunctional compounds …
therapeutic strategy [1]. While the inherent complexity of these bifunctional compounds …
Ion channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodies
TJ Morgenstern, A Darko-Boateng, E Afriyie… - bioRxiv, 2024 - biorxiv.org
Targeted recruitment of E3 ubiquitin ligases to degrade traditionally undruggable proteins is
a disruptive paradigm for developing new therapeutics. Two salient limitations are that< 2 …
a disruptive paradigm for developing new therapeutics. Two salient limitations are that< 2 …
Programmable Protein Editing with Language Model-Derived Peptide Guides
T Wang - 2024 - cdr.lib.unc.edu
Proteins perform a variety of different functions in the human body. Dysregulation of these
protein pathways can result in many diseases, including cancer. While protein degradation …
protein pathways can result in many diseases, including cancer. While protein degradation …