A meta-analysis of pro-inflammatory cytokines in autism spectrum disorders: Effects of age, gender, and latitude

A Saghazadeh, B Ataeinia, K Keynejad… - Journal of psychiatric …, 2019 - Elsevier
Background Autism spectrum disorders (ASD) occur in 1.5% of the general population
worldwide. Studies suggest that ASD might have more costs than diabetes and attention …

A systematic review of the valproic-acid-induced rodent model of autism

D Chaliha, M Albrecht, M Vaccarezza… - Developmental …, 2020 - karger.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by
repetitive behaviours, cognitive rigidity/inflexibility, and social-affective impairment …

The sphingosine 1-phosphate receptor modulator fingolimod as a therapeutic agent: Recent findings and new perspectives

A Huwiler, U Zangemeister-Wittke - Pharmacology & therapeutics, 2018 - Elsevier
The immunomodulatory drug fingolimod (FTY720, Gilenya R) was approved for oral
treatment of relapsing-remitting multiple sclerosis, due to its impressive efficacy and good …

[HTML][HTML] Microglia and CNS interleukin-1: beyond immunological concepts

X Liu, N Quan - Frontiers in neurology, 2018 - frontiersin.org
Activation of microglia and expression of the inflammatory cytokine interleukin-1 (IL-1) in the
CNS have become almost synonymous with neuroinflammation. In numerous studies …

[HTML][HTML] Selenium inhibits ferroptosis and ameliorates autistic-like behaviors of BTBR mice by regulating the Nrf2/GPx4 pathway

H Wu, Y Luan, H Wang, P Zhang, S Liu, P Wang… - Brain research …, 2022 - Elsevier
Background Autism spectrum disorder (ASD) is a group of extensive neurodevelopmental
disorders for which few efficacious drugs are available. Sodium selenite (Se), the most …

Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?

P Klein, A Friedman, MQ Hameed, RM Kaminski… - …, 2020 - Wiley Online Library
Prevention of epilepsy is a great unmet need. Acute central nervous system (CNS) insults
such as traumatic brain injury (TBI), cerebrovascular accidents (CVA), and CNS infections …

[HTML][HTML] Immune abnormalities in autism spectrum disorder—could they hold promise for causative treatment?

D Gładysz, A Krzywdzińska, KK Hozyasz - Molecular neurobiology, 2018 - Springer
Autism spectrum disorders (ASD) are characterized by impairments in language and
communication development, social behavior, and the occurrence of stereotypic patterns of …

[HTML][HTML] Supplementation with selenium attenuates autism-like behaviors and improves oxidative stress, inflammation and related gene expression in an autism …

H Wu, G Zhao, S Liu, Q Zhang, P Wang, Y Cao… - The Journal of Nutritional …, 2022 - Elsevier
Autism spectrum disorder (ASD) refers to a group of neurodevelopmental disorders. The
etiology and pathological mechanisms of ASD are still unknown, and its prognosis is poor …

The impact of glutathione metabolism in autism spectrum disorder

G Bjørklund, MD Doşa, M Maes, M Dadar… - Pharmacological …, 2021 - Elsevier
This paper reviews the potential role of glutathione (GSH) in autism spectrum disorder
(ASD). GSH plays a key role in the detoxification of xenobiotics and maintenance of balance …

[HTML][HTML] Three decades of valproate: a current model for studying autism Spectrum disorder

D Zarate-Lopez, AL Torres-Chávez… - Current …, 2023 - ncbi.nlm.nih.gov
Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with increased
prevalence and incidence in recent decades. Its etiology remains largely unclear, but it …