Background Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease
causing severe locomotor disability and deterioration in the quality of life. Existing treatments …

Herbal medicines have been used to prevent and cure diseases in eastern countries for
thousands of years. In recent decades, these phytotherapies are becoming more and more …

Sinomenine (SIN) has long been used as a therapeutic agent of rheumatoid arthritis (RA) in
China. However, the discrepancy between low oral bioavailability and higher minimal …

Lung cancer is the leading cause of cancer deaths worldwide, with a high morbidity and less
than 20% survival rate. Therefore, new treatment strategies and drugs are needed to reduce …

Sinomenine hydrochloride (SH) is an ideal drug for the treatment of rheumatoid arthritis and
osteoarthritis. However, high plasma concentration of systemically administered SH can …

Sinomenine, a bioactive alkaloid isolated from the traditional Chinese herb Sinomenium
acutum, possesses antiinflammatory, antinociceptive, antifibrotic, and antitumorigenic …

Sinomenine is a bioactive alkaloid isolated from the Chinese medicinal plant Sinomenium
acutum (Thunb.) Rehd. et Wils which exhibits significant analgesic, anti-inflammatory, and …

In situ gels containing sinomenine hydrochloride (SMH) for intra-articular (IA) administration
to treat rheumatoid arthritis (RA) were designed and investigated in this study. Glycerol …

Certain non-steroidal anti-inflammatory drugs may possess anti-tumorigenic effects in
certain cancer cell types. Sinomenine (SIN) is an alkaloid from Sinomenium acutum, a …

The goal of this paper was to develop and evaluate dual component-loaded with the
hydrophilic sinomenine hydrochloride (SH) and lipophilic cinnamaldehyde (CA) cubic liquid …