Background Recent research on the implications of gut microbiota on brain functions has
helped to gather important information on the relationship between them. Pathogenesis of …

Most neurodegenerative disorders are diseases of protein homeostasis, with misfolded
aggregates accumulating. The neurodegenerative process is mediated by numerous …

Bile acids are best known as detergents involved in the digestion of lipids. In addition, new
data in the last decade have shown that bile acids also function as gut hormones capable of …

In the mitochondrial pathway of apoptosis, caspase activation is closely linked to
mitochondrial outer membrane permeabilization (MOMP). Numerous pro-apoptotic signal …

Bile acids are signalling hormones involved in the regulation of several metabolic pathways.
The ability of bile acids to bind and signal through their receptors is modulated by the gut …

Bile acids are commonly known as digestive agents for lipids. The mechanisms of bile acids
in the gastrointestinal track during normal physiological conditions as well as hepatic and …

Bile acids, mainly ursodeoxycholic acid (UDCA) and its conjugated species
glycoursodeoxycholic acid (GUDCA) and tauroursodeoxycholic acid (TUDCA) have long …

Bear bile has been used in Traditional Chinese Medicine for thousands of years due to its
therapeutic potential and clinical applications. The tauroursodeoxycholic acid (TUDCA), one …

Intracerebral hemorrhage (ICH) is a devastating form of stroke with high rates of mortality
and morbidity. It induces cell death that is responsible for neurological deficits postinjury …

Spinal cord injury (SCI), as one of the intractable diseases in clinical medicine, affects
thousands of human beings, and the pathologic changes after injury have been a hot spot …