Despite recent medical advances, atherosclerosis is a global burden accounting for
numerous deaths and hospital admissions. Immune-mediated inflammation is a major …

The complement system has been implicated in obesity, fatty liver, diabetes and
cardiovascular disease (CVD). Complement factors are produced in adipose tissue and …

For decades, complement has been recognized as an effector arm of the immune system
that contributes to the destruction of tumor cells. In fact, many therapeutic strategies have …

Abundant reports have shown that there is a strong relationship between C3 and C3a-
desArg levels, adipose tissue, and risk factors for cardiovascular disease, metabolic …

There is now growing evidence that psoriasis, like other inflammatory diseases such as
rheumatoid arthritis and systemic lupus erythematosus, is a systemic disorder that is …

The past few years have proven to be a highly successful and exciting period for the field of
complement-directed drug discovery and development. Driven by promising experiences …

This review summarizes available evidence on the role of serum complement component 3
(C3), produced by liver, adipocytes and activated macrophages at inflammation sites, and …

Background: Chondroitin sulfate (CS) is a glycosaminoglycan released by activated
platelets. Objective: Here we test the hypothesis that CS released by activated platelets can …

Background In several reports, C3 and C4 have been linked to diabetes and cardiovascular
disease (CVD). Here, we investigate this link and the degree of C3 activation in elderly …

Introduction Inflammation has been implicated in the development of atherosclerosis in
patients with acute coronary syndrome. C-reactive protein is an established nonspecific …